European Radiology

, Volume 21, Issue 1, pp 188–196 | Cite as

Ultra-high-b-value diffusion-weighted MR imaging for the detection of prostate cancer: evaluation in 201 cases with histopathological correlation

  • Kazuhiro Katahira
  • Taro Takahara
  • Thomas C. Kwee
  • Seitaro Oda
  • Yasuko Suzuki
  • Shoji Morishita
  • Kosuke Kitani
  • Yasuyuki Hamada
  • Mitsuhiko Kitaoka
  • Yasuyuki Yamashita



To assess the diagnostic performance of diffusion-weighted magnetic resonance (MR) imaging (DWI) for prostate cancer detection, using different b-values.


A total of 201 patients who underwent MR imaging before total prostatectomy were evaluated. MR images were independently assessed by three radiologists. Three combinations of sequences were separately evaluated, as follows: group 1 [T2-weighted images (T2WI) alone], group 2 (T2WI and DWI with a b-value of 1,000 s/mm2), group 3 (T2WI and DWI with a b-value of 2,000 s/mm2). Whole-mount-section histopathological examination was the reference standard. Areas under the receiver operating characteristic curve (AUCs) and diagnostic performance parameters were determined.


The sensitivity, specificity, and AUC for the detection of prostate cancer were as follows: 52.2%, 80.7%, and 0.694 in group 1; 61.2%, 82.6%, and 0.755 in group 2; 73.2%, 89.7%, and 0.842 in group 3. Group 3 achieved the highest diagnostic performance, followed by group 2 (P < 0.05). In the transition zone, the specificity was lower (P < 0.001) for group 2 (82.2%) than for group 1 (86.2%).


The addition of diffusion-weighted images with a b-value of 2,000 s/mm2 to T2WI can improve the diagnostic performance of MR imaging in prostate cancer detection.


Prostate cancer Diffusion-weighted imaging Ultra-high b-value MRI Histopathological correlation 


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Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Kazuhiro Katahira
    • 1
  • Taro Takahara
    • 2
  • Thomas C. Kwee
    • 2
  • Seitaro Oda
    • 1
  • Yasuko Suzuki
    • 1
  • Shoji Morishita
    • 1
  • Kosuke Kitani
    • 3
  • Yasuyuki Hamada
    • 3
  • Mitsuhiko Kitaoka
    • 4
  • Yasuyuki Yamashita
    • 5
  1. 1.Department of RadiologyKumamoto Chuo HospitalKumamotoJapan
  2. 2.Department of RadiologyUniversity Medical Center UtrechtUtrechtThe Netherlands
  3. 3.Department of UrologyKumamoto Chuo HospitalKumamotoJapan
  4. 4.Department of PathologyKumamoto Chuo HospitalKumamotoJapan
  5. 5.Department of RadiologyUniversity of KumamotoKumamotoJapan

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