European Radiology

, Volume 20, Issue 12, pp 2925–2932 | Cite as

Regional impairment of 18F-FDG uptake in the cervical spinal cord in patients with monosegmental chronic cervical myelopathy

  • Frank Willi Floeth
  • Gabriele Stoffels
  • Jörg Herdmann
  • Paul Jansen
  • Wolfgang Meyer
  • Hans-Jakob Steiger
  • Karl-Josef Langen
Head and Neck



The aim of this preliminary report was to assess glucose metabolism in the cervical spine of patients with chronic compressive myelopathy by using FDG PET.


Ten patients with monosegmental chronic degenerative stenosis and local cord compression of the upper/middle cervical spine with signs of myelopathy on MRI and 10 control patients without known cervical abnormalities were investigated by FDG PET. Maximum standardised uptake values (SUVmax) were measured at all levels of the cervical spine (C1–C7).


While the controls showed the typical pattern of homogeneous linear FDG uptake along the entire cervical cord, the patients with chronic compressive myelopathy had a normal glucose utilisation only above the level of stenosis and a significant decrease in FDG uptake below their individual level of cord compression. This may be caused by atrophy of anterior grey horn cells and the loss of glucose-consuming neurons below the level of cord compression.


FDG PET of the spine of patients with chronic compressive myelopathy may be helpful to determine the stage and severity of cervical myelopathy.


FDG PET Cervical spinal cord Cervical myelopathy Degenerative spinal stenosis 


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Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Frank Willi Floeth
    • 1
    • 4
  • Gabriele Stoffels
    • 2
  • Jörg Herdmann
    • 1
    • 4
  • Paul Jansen
    • 3
  • Wolfgang Meyer
    • 3
  • Hans-Jakob Steiger
    • 1
  • Karl-Josef Langen
    • 2
    • 5
  1. 1.Department of NeurosurgeryHeinrich Heine UniversityDüsseldorfGermany
  2. 2.Institute of Neuroscience and MedicineForschungszentrum JülichJülichGermany
  3. 3.Central Institute of Applied MathematicsForschungszentrum JülichJülichGermany
  4. 4.Department of Spine and PainSt. Vinzenz HospitalDüsseldorfGermany
  5. 5.Institute of Neuroscience and Medicine, INM-4 (Brain Imaging Physics)Forschungszentrum JülichJülichGermany

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