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European Radiology

, Volume 20, Issue 9, pp 2265–2273 | Cite as

Detection of hepatic metastases by superparamagnetic iron oxide-enhanced MR imaging: prospective comparison between 1.5-T and 3.0-T images in the same patients

  • Keitaro Sofue
  • Masakatsu TsurusakiEmail author
  • Mototaka Miyake
  • Aine Sakurada
  • Yasuaki Arai
  • Kazuro Sugimura
Hepatobiliary-Pancreas

Abstract

Objective:

To prospectively compare the diagnostic performance of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging at 3.0 T and 1.5 T for detection of hepatic metastases.

Methods:

A total of 28 patients (18 men, 10 women; mean age, 61 years) with 80 hepatic metastases were prospectively examined by SPIO-enhanced MR imaging at 3.0 T and 1.5 T. T1-weighted gradient-recalled-echo (GRE) images, T2*-weighted GRE images and T2-weighted fast spin-echo (SE) images were acquired. The tumour-to-liver contrast-to-noise ratio (CNR) of the lesions was calculated. Three observers independently reviewed each image. Image artefacts and overall image quality were analysed, sensitivity and positive predictive value for the detection of hepatic metastases were calculated, and diagnostic accuracy using the receiver-operating characteristics (ROC) method was evaluated.

Results:

The tumour-to-liver CNRs were significantly higher at 3.0 T. Chemical shift and motion artefact were more severe, and overall image quality was worse on T2-weighted fast SE images at 3.0 T. Overall image quality of the two systems was similar on T1-weighted GRE images and T2*-weighted GRE images. Sensitivity and area under the ROC curve for the 3.0-T image sets were significantly higher.

Conclusion:

SPIO-enhanced MR imaging at 3.0 T provided better diagnostic performance for detection of hepatic metastases than 1.5 T.

Keywords

Hepatic metastasis Magnetic resonance imaging Superparamagnetic iron oxide 

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Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Keitaro Sofue
    • 1
  • Masakatsu Tsurusaki
    • 1
    • 3
    Email author
  • Mototaka Miyake
    • 1
  • Aine Sakurada
    • 1
  • Yasuaki Arai
    • 1
  • Kazuro Sugimura
    • 2
  1. 1.Department of RadiologyNational Cancer CenterTokyoJapan
  2. 2.Department of Radiology, Graduate School of MedicineKobe UniversityKobeJapan
  3. 3.Division of Diagnostic RadiologyNational Cancer Center HospitalChuo-kuJapan

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