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European Radiology

, Volume 20, Issue 8, pp 2005–2012 | Cite as

Roles of myocardial blood volume and flow in coronary artery disease: an experimental MRI study at rest and during hyperemia

  • Kyle S. McCommis
  • Thomas A. Goldstein
  • Dana R. Abendschein
  • Bernd Misselwitz
  • Thomas Pilgram
  • Robert J. Gropler
  • Jie ZhengEmail author
Magnetic Resonance

Abstract

Objective

To validate fast perfusion mapping techniques in a setting of coronary artery stenosis, and to further assess the relationship of absolute myocardial blood volume (MBV) and blood flow (MBF) to global myocardial oxygen demand.

Methods

A group of 27 mongrel dogs were divided into 10 controls and 17 with acute coronary stenosis. On 1.5-T MRI, first-pass perfusion imaging with a bolus injection of a blood-pool contrast agent was performed to determine myocardial perfusion both at rest and during either dipyridamole-induced vasodilation or dobutamine-induced stress. Regional values of MBF and MBV were quantified by using a fast mapping technique. Color microspheres and 99mTc-labeled red blood cells were injected to obtain respective gold standards.

Results

Microsphere-measured MBF and 99mTc-measured MBV reference values correlated well with the MR results. Given the same changes in MBF, changes in MBV are twofold greater with dobutamine than with dipyridamole. Under dobutamine stress, MBV shows better association with total myocardial oxygen demand than MBF. Coronary stenosis progressively reduced this association in the presence of increased stenosis severity.

Conclusions

MR first-pass perfusion can rapidly estimate regional MBF and MBV. Absolute quantification of MBV may add additional information on stenosis severity and myocardial viability compared with standard qualitative clinical evaluations of myocardial perfusion.

Keywords

Coronary stenosis Myocardial blood flow Myocardial blood volume 

Notes

Acknowledgements

This work was supported by a grant from the National Institutes of Health R01 HL74019-01

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Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Kyle S. McCommis
    • 1
  • Thomas A. Goldstein
    • 1
  • Dana R. Abendschein
    • 2
  • Bernd Misselwitz
    • 3
  • Thomas Pilgram
    • 1
  • Robert J. Gropler
    • 1
    • 2
  • Jie Zheng
    • 1
    • 4
    Email author
  1. 1.Mallinckrodt Institute of RadiologyWashington University School of MedicineSt. LouisUSA
  2. 2.Center for Cardiovascular ResearchWashington University School of MedicineSt. LouisUSA
  3. 3.Bayer Schering Pharma AGBerlinGermany
  4. 4.Cardiovascular Imaging LabSt. LouisUSA

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