European Radiology

, Volume 20, Issue 3, pp 696–703

Real-time fMRI feedback training may improve chronic tinnitus

Neuro

DOI: 10.1007/s00330-009-1595-z

Cite this article as:
Haller, S., Birbaumer, N. & Veit, R. Eur Radiol (2010) 20: 696. doi:10.1007/s00330-009-1595-z

Abstract

Objectives

Tinnitus consists of a more or less constant aversive tone or noise and is associated with excess auditory activation. Transient distortion of this activation (repetitive transcranial magnetic stimulation, rTMS) may improve tinnitus. Recently proposed operant training in real-time functional magnetic resonance imaging (rtfMRI) neurofeedback allows voluntary modification of specific circumscribed neuronal activations. Combining these observations, we investigated whether patients suffering from tinnitus can (1) learn to voluntarily reduce activation of the auditory system by rtfMRI neurofeedback and whether (2) successful learning improves tinnitus symptoms.

Methods

Six participants with chronic tinnitus were included. First, location of the individual auditory cortex was determined in a standard fMRI auditory block-design localizer. Then, participants were trained to voluntarily reduce the auditory activation (rtfMRI) with visual biofeedback of the current auditory activation.

Results

Auditory activation significantly decreased after rtfMRI neurofeedback. This reduced the subjective tinnitus in two of six participants.

Conclusion

These preliminary results suggest that tinnitus patients learn to voluntarily reduce spatially specific auditory activations by rtfMRI neurofeedback and that this may reduce tinnitus symptoms. Optimized training protocols (frequency, duration, etc.) may further improve the results.

Keywords

fMRI BOLD Biofeedback Tinnitus Neurofeedback 

Abbreviations

BOLD

blood oxygenation level dependent

DLPFC

dorso-lateral prefrontal cortex

EEG

electroencephalography

EPI

echoplanar imaging

fMRI

functional magnetic resonance imaging

rtfMRI

real-time functional magnetic resonance imaging

rTMS

repetitive transcranial magnetic stimulation

VLPFC

ventro-lateral prefrontal cortex

Copyright information

© European Society of Radiology 2009

Authors and Affiliations

  1. 1.Institute of Radiology, Department of NeuroradiologyUniversity Hospital BaselBaselSwitzerland
  2. 2.Institute of NeuroradiologyDepartment of Imaging and Medical Informatics, Geneva University HospitalGenevaSwitzerland
  3. 3.Institute of Medical Psychology and Behavioral NeurobiologyUniversity of TübingenTübingenGermany
  4. 4.Ospedale San CamilloInstituto di Ricovero e Cura a Carattere ScientificoVeneziaItaly

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