European Radiology

, Volume 20, Issue 2, pp 432–442 | Cite as

Simulation-based comparison of two approaches frequently used for dynamic contrast-enhanced MRI

  • Stefan Zwick
  • Gunnar Brix
  • Paul S. Tofts
  • Ralph Strecker
  • Annette Kopp-Schneider
  • Hendrik Laue
  • Wolfhard Semmler
  • Fabian Kiessling
Magnetic Resonance



The purpose was to compare two approaches for the acquisition and analysis of dynamic-contrast-enhanced MRI data with respect to differences in the modelling of the arterial input-function (AIF), the dependency of the model parameters on physiological parameters and their numerical stability. Eight hundred tissue concentration curves were simulated for different combinations of perfusion, permeability, interstitial volume and plasma volume based on two measured AIFs and analysed according to the two commonly used approaches. The transfer constants (Approach 1) K trans and (Approach 2) k ep were correlated with all tissue parameters. K trans showed a stronger dependency on perfusion, and k ep on permeability. The volume parameters (Approach 1) v e and (Approach 2) A were mainly influenced by the interstitial and plasma volume. Both approaches allow only rough characterisation of tissue microcirculation and microvasculature. Approach 2 seems to be somewhat more robust than 1, mainly due to the different methods of CA administration.


Magnetic resonance imaging DCE-MRI Pharmacokinetic modelling MMID4 AIF 



We thank the Bundesministerium für Bildung und Forschung (BMBF) for the financial support (contract grant name: NanoAG; contract grant number: 13N8873). The authors thank Gary M. Raymond from the Department of Bioengineering, University of Washington, Seattle, Washington for his valuable help in using MMID4.

Conflict of interest

Dr. Ralph Strecker is an employee of Siemens AG, Healthcare Sector, Erlangen, Germany


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Copyright information

© European Society of Radiology 2009

Authors and Affiliations

  • Stefan Zwick
    • 1
    • 2
    • 3
  • Gunnar Brix
    • 4
  • Paul S. Tofts
    • 5
  • Ralph Strecker
    • 1
  • Annette Kopp-Schneider
    • 6
  • Hendrik Laue
    • 7
  • Wolfhard Semmler
    • 2
  • Fabian Kiessling
    • 8
  1. 1.Siemens AG, Healthcare SectorErlangenGermany
  2. 2.Department of Medical Physics in RadiologyGerman Cancer Research Center (DKFZ)HeidelbergGermany
  3. 3.Department of Diagnostic Radiology, Medical PhysicsUniversity Hospital FreiburgFreiburgGermany
  4. 4.Department of Medical and Occupational Radiation ProtectionFederal Office for Radiation ProtectionMunichGermany
  5. 5.Imaging PhysicsBrighton and Sussex Medical SchoolFalmer, SussexUK
  6. 6.BiostatisticsGerman Cancer Research Center (DKFZ)HeidelbergGermany
  7. 7.Fraunhofer MEVISBremenGermany
  8. 8.Experimental Molecular Imaging, Medical FacultyRWTH-Aachen UniversityAachenGermany

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