European Radiology

, Volume 20, Issue 1, pp 48–55 | Cite as

Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI

  • Olivier Rouvière
  • Nicolas Girouin
  • Ludivine Glas
  • Alexandre Ben Cheikh
  • Albert Gelet
  • Florence Mège-Lechevallier
  • Muriel Rabilloud
  • Jean-Yves Chapelon
  • Denis Lyonnet
Urogenital

Abstract

The objective was to evaluate T2-weighted (T2w) and dynamic contrast-enhanced (DCE) MRI in detecting local cancer recurrences after prostate high-intensity focused ultrasound (HIFU) ablation. Fifty-nine patients with biochemical recurrence after prostate HIFU ablation underwent T2-weighted and DCE MRI before transrectal biopsy. For each patient, biopsies were performed by two operators: operator 1 (blinded to MR results) performed random and colour Doppler-guided biopsies (“routine biopsies”); operator 2 obtained up to three cores per suspicious lesion on MRI (“targeted biopsies”). Seventy-seven suspicious lesions were detected on DCE images (n = 52), T2w images (n = 2) or both (n = 23). Forty patients and 41 MR lesions were positive at biopsy. Of the 36 remaining MR lesions, 20 contained viable benign glands. Targeted biopsy detected more cancers than routine biopsy (36 versus 27 patients, p = 0.0523). The mean percentages of positive cores per patient and of tumour invasion of the cores were significantly higher for targeted biopsies (p < 0.0001). The odds ratios of the probability of finding viable cancer and viable prostate tissue (benign or malignant) at targeted versus routine biopsy were respectively 3.35 (95% CI 3.05–3.64) and 1.38 (95% CI 1.13–1.63). MRI combining T2-weighted and DCE images is a promising method for guiding post-HIFU biopsy towards areas containing recurrent cancer and viable prostate tissue.

Keywords

Prostate cancer MRI Dynamic-contrast enhanced MRI Biochemical recurrence HIFU 

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Copyright information

© European Society of Radiology 2009

Authors and Affiliations

  • Olivier Rouvière
    • 1
    • 2
    • 3
    • 8
  • Nicolas Girouin
    • 1
    • 2
    • 3
  • Ludivine Glas
    • 1
    • 2
    • 3
  • Alexandre Ben Cheikh
    • 1
    • 2
    • 3
  • Albert Gelet
    • 4
    • 8
  • Florence Mège-Lechevallier
    • 5
  • Muriel Rabilloud
    • 6
    • 7
  • Jean-Yves Chapelon
    • 8
  • Denis Lyonnet
    • 1
    • 2
    • 3
    • 8
  1. 1.Hospices Civils de Lyon, Department of Urinary and Vascular RadiologyHôpital Edouard HerriotLyonFrance
  2. 2.Université de LyonLyonFrance
  3. 3.Faculté de médecine Lyon NordUniversité de Lyon 1LyonFrance
  4. 4.Hospices Civils de Lyon, Department of UrologyHôpital Edouard HerriotLyonFrance
  5. 5.Hospices Civils de Lyon, Department of PathologyHôpital Edouard HerriotLyonFrance
  6. 6.Hospices Civils de Lyon, Department of BiostatisticsLyonFrance
  7. 7.Université de Lyon 1, UMR CNRS 5558, Laboratoire Biostatistiques-SantéPierre-BéniteFrance
  8. 8.Inserm, U556LyonFrance

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