Comparison of sonographically measured bowel wall vascularity, histology, and disease activity in Crohn’s disease
- 358 Downloads
The purposes of this study was to provide a retrospective comparison of semiquantitatively measured bowel wall vascularity by power Doppler sonography, endoscopic-histopathological biopsy findings, and disease activity in patients with confirmed Crohn’s disease. Thirty-two out of 1,332 patients with histologically confirmed Crohn’s disease (18 female, 14 male; mean age 38.8 years) met the inclusion criteria: ileocolonoscopy with biopsy and power Doppler sonographic determination of bowel wall vascularity with assessment of disease activity within a period of 5 days. Sonographic determination of bowel wall vascularity was based on a semiquantitative score. Endoscopic bowel wall biopsy specimens were assessed using a self-developed inflammation score and the disease activity was calculated using Crohn’s disease activity index (CDAI). A significant association (p < 0.05) was shown for results of histology and bowel wall vascularity in the terminal ileum (κ = 0.66; sensitivity 95%; specificity 69%). There was no observed association between CDAI and histology, although there was an association between CDAI and bowel wall vascularity (sensitivity 82%). Increased bowel wall vascularity in the terminal ileum measured by power Doppler ultrasound reflects inflammatory activity in histologically examined bowel wall. Power Doppler ultrasound may be able to monitor activity changes of the bowel wall determined by pharmaceutical treatment.
KeywordsCrohn’s disease Disease activity Ultrasonography Bowel wall vascularity
- 12.Serra C, Menozzi G, Labate AM et al (2007) Ultrasound assessment of vascularization of the thickened terminal ileum wall in Crohn’s disease patients using a low-mechanical index real-time scanning technique with a second generation ultrasound contrast agent. Eur J Radiol 62:114–121PubMedCrossRefGoogle Scholar
- 21.Stange EF, Travis SP, Vermeire S et al (2006) European Crohn’s and colitis organisation. European evidence based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis. Gut 55 Suppl 1:11–15Google Scholar
- 23.Geboes K, Dalle I (2002) Influence of treatment on morphological features of mucosal inflammation. Gut 50 Suppl 3:37–42Google Scholar
- 27.Bender R, Ziegler A, Lange S (2002) Logistische regression. Dtsch Med Wochenschr 127:T11–T13Google Scholar