European Radiology

, Volume 19, Issue 6, pp 1328–1334

Bronchial morphometry in smokers: comparison with healthy subjects by using 3D CT

  • Michel Montaudon
  • Patrick Berger
  • Mathieu Lederlin
  • Roger Marthan
  • José Manuel Tunon-de-Lara
  • François Laurent
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Abstract

The assessment of airway dimensions in patients with airway disease by using computed tomography (CT) has been limited by the obliquity of bronchi, the ability to identify the bronchial generation, and the limited number of bronchial measurements. The aims of the present study were (i) to analyze cross-sectional bronchial dimensions after automatic orthogonal reconstruction of all visible bronchi on CT images, and (ii) to compare bronchial morphometry between smokers and nonsmokers. CT and pulmonary function tests were performed in 18 males separated into two groups: 9 nonsmokers and 9 smokers. Bronchial wall area (WA) and lumen area (LA) were assessed using dedicated 3D software able to provide accurate cross-sectional measurements of all visible bronchi on CT. WA/LA and WA/(WA+LA) ratios were computed and all parameters were compared between both groups. Smokers demonstrated greater WA, smaller LA, and consequently greater LA/WA and LA/(WA+LA) ratios than nonsmokers. These differences occurred downward starting at the fourth bronchial generation. 3D quantitative CT method is able to demonstrate significant changes in bronchial morphometry related to tobacco consumption.

Keywords

Airway Computed tomography Smokers Image analysis 

Copyright information

© European Society of Radiology 2009

Authors and Affiliations

  • Michel Montaudon
    • 1
    • 2
    • 3
    • 6
  • Patrick Berger
    • 2
    • 3
    • 4
  • Mathieu Lederlin
    • 1
  • Roger Marthan
    • 2
    • 3
    • 4
  • José Manuel Tunon-de-Lara
    • 2
    • 3
    • 5
  • François Laurent
    • 1
    • 2
    • 3
  1. 1.CHU de BordeauxUnité d’Imagerie ThoraciquePessacFrance
  2. 2.Laboratoire de Physiologie Cellulaire RespiratoireUniversité Bordeaux 2BordeauxFrance
  3. 3.INSERMBordeauxFrance
  4. 4.CHU de BordeauxService d’Exploration Fonctionnelle RespiratoirePessacFrance
  5. 5.CHU de BordeauxService des Maladies RespiratoiresPessacFrance
  6. 6.Unité d’Imagerie ThoraciqueHopital CardiologiquePessacFrance

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