European Radiology

, Volume 19, Issue 1, pp 103–109 | Cite as

Head and neck squamous cell carcinoma: usefulness of diffusion-weighted MR imaging in the prediction of a neoadjuvant therapeutic effect

  • Hiroki Kato
  • Masayuki Kanematsu
  • Osamu Tanaka
  • Keisuke Mizuta
  • Mitsuhiro Aoki
  • Toshiyuki Shibata
  • Tomomi Yamashita
  • Yoshinobu Hirose
  • Hiroaki Hoshi
Head and Neck


The purpose of our study was to evaluate the usefulness of diffusion-weighted imaging in predicting the responses to neoadjuvant therapy for head and neck squamous cell carcinomas. Diffusion-weighted, T2-weighted, and gadolinium-enhanced T1-weighted images were obtained from 28 patients with untreated head and neck squamous cell carcinomas with histological proof. A blinded radiologist evaluated the quantitative and qualitative signal intensities and apparent diffusion coefficients (ADCs) in the lesions on each sequence. All patients were treated by neoadjuvant therapies, and the post-therapeutic tumor regression rate was determined. Both the quantitative and qualitative signal intensities on diffusion-weighted images showed positive correlations (r = 0.367 and 0.412, p < .05), and the ADCs showed a weak, inversed correlation (r = −0.384, p < .05) with the tumor regression rates. Diffusion-weighted imaging including an assessment by ADCs may be able to predict tumor response to neoadjuvant therapy for head and neck squamous cell carcinomas.


Diffusion-weighted imaging Squamous cell carcinoma Head and neck Neoadjuvant therapy 


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Copyright information

© European Society of Radiology 2008

Authors and Affiliations

  • Hiroki Kato
    • 1
  • Masayuki Kanematsu
    • 1
    • 2
  • Osamu Tanaka
    • 1
  • Keisuke Mizuta
    • 3
  • Mitsuhiro Aoki
    • 3
  • Toshiyuki Shibata
    • 4
  • Tomomi Yamashita
    • 4
  • Yoshinobu Hirose
    • 5
  • Hiroaki Hoshi
    • 1
  1. 1.Department of RadiologyGifu University School of MedicineGifuJapan
  2. 2.High-level Imaging Diagnosis CenterGifu University HospitalGifuJapan
  3. 3.Department of OtolaryngologyGifu University School of MedicineGifuJapan
  4. 4.Department of Oral and Maxillofacial SciencesGifu University Graduate School of MedicineGifuJapan
  5. 5.Department of PathologyGifu University School of MedicineGifuJapan

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