European Radiology

, 19:172

Can abdominal multi-detector CT diagnose spinal osteoporosis?

  • Antonios E. Papadakis
  • Apostolos H. Karantanas
  • Giorgos Papadokostakis
  • Effie Petinellis
  • John Damilakis


The aim of this study was to (1) generate quantitative CT (QCT) densitometric data based on routine abdominal multi-detector (MDCT) examinations and (2) investigate whether these data can be used to differentiate osteoporotic from healthy females. Twenty-five female patients (group A) with a history of radiotherapy were examined both with routine abdominal MDCT and standard QCT to generate a MDCT-to-QCT conversion equation. Twenty-one osteoporotic (group B) and 23 healthy female patients (group C) were also recruited in the study. Patients of groups B and C underwent routine abdominal MDCT examination for various clinical indications. Mean bone mineral density (BMD) in patients of group A was 103.4 mg/ml ± 32.8 with routine abdominal MDCT and 91.0 mg/ml ± 28.5 with QCT. Quantitative CT BMDQCT values for patients in groups B and C were calculated utilizing the BMDMDCT values derived from routine abdominal MDCT data sets and the MDCT to QCT conversion equation: \({\text{BMD}}_{{\text{QCT}}} = 0.78 \cdot {\text{BMD}}_{{\text{MDCT}}} + 10.13\). The calculated QCT densitometric data adequately differentiated osteoporotic from healthy females (area under ROC curve 0.828, p = 0.05). In conclusion, this study showed that in a group of female patients, QCT data derived from routine abdominal MDCT examinations discriminated osteoporotic from healthy subjects.


Osteoporosis Multi-detector CT Abdominal imaging CT densitometry Image analysis 


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Copyright information

© European Society of Radiology 2008

Authors and Affiliations

  • Antonios E. Papadakis
    • 1
  • Apostolos H. Karantanas
    • 2
  • Giorgos Papadokostakis
    • 3
  • Effie Petinellis
    • 4
  • John Damilakis
    • 1
  1. 1.Department of Medical Physics, Faculty of MedicineUniversity of CreteIraklionGreece
  2. 2.Department of Radiology, Faculty of MedicineUniversity of CreteIraklionGreece
  3. 3.Department of Orthopedics, Faculty of MedicineUniversity Hospital of HeraklionIraklionGreece
  4. 4.Department of Radiotherapy, Faculty of MedicineUniversity Hospital of HeraklionIraklionGreece

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