European Radiology

, Volume 18, Issue 11, pp 2414–2424 | Cite as

Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience

  • Balazs Ruzsics
  • Heon Lee
  • Peter L. Zwerner
  • Mulugeta Gebregziabher
  • Philip Costello
  • U. Joseph SchoepfEmail author
Cardiac Imaging


We aimed to evaluate the feasibility of diagnosing coronary stenosis and myocardial ischemia with a single dual-energy CT (DECT) acquisition. Thirty-five patients underwent contrast-enhanced, ECG-gated DECT of the heart while independently operating the two tubes of a dual-source CT system at high- and low-energy X-ray spectra. From the same raw data, coronary CTA (cCTA) studies were reconstructed for stenosis detection, and the myocardial blood-pool was analyzed by determining the tissue iodine content. Two independent observers analyzed all studies for stenosis and myocardial blood-pool deficits. Results were correlated with SPECT, coronary catheterization and cCTA on a segmental basis. cCTA had 98% sensitivity, 88% specificity and 92% accuracy for detection of >50% stenosis. DECT detected myocardial ischemia with 84% sensitivity, 94% specificity and 92% accuracy. Our initial experience may warrant further exploration of DECT as a possibly feasible single imaging investigation for the comprehensive diagnosis of coronary stenosis and myocardial ischemia.


Single Photon Emission Compute Tomography Myocardial Perfusion Imaging Coronary Artery Stenosis Coronary Catheterization Stenosis Detection 
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Supplementary material

330_2008_1022_MOESM1_ESM.avi (13 mb)


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Copyright information

© European Society of Radiology 2008

Authors and Affiliations

  • Balazs Ruzsics
    • 1
  • Heon Lee
    • 1
    • 2
  • Peter L. Zwerner
    • 1
    • 3
  • Mulugeta Gebregziabher
    • 4
  • Philip Costello
    • 1
  • U. Joseph Schoepf
    • 1
    • 3
    Email author
  1. 1.Department of RadiologyMedical University of South CarolinaCharlestonUSA
  2. 2.Department of RadiologySeoul Medical CenterSeoulSouth Korea
  3. 3.Division of CardiologyMedical University of South CarolinaCharlestonUSA
  4. 4.Department of Biostatistics, Bioinformatics, and EpidemiologyMedical University of South CarolinaCharlestonUSA

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