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European Radiology

, 18:2040 | Cite as

Performance of FDG-PET/CT for diagnosis of recurrent uterine cervical cancer

  • Kazuhiro KitajimaEmail author
  • Koji Murakami
  • Erena Yamasaki
  • Yasushi Domeki
  • Yasushi Kaji
  • Kazuro Sugimura
Nuclear Medicine

Abstract

The purpose is to evaluate the accuracy of integrated FDG-PET/CT, compared with PET alone, for diagnosis of suspected recurrence of uterine cervical cancer. Fifty-two women who had undergone treatment for histopathologically proven cervical cancer received PET/CT with suspected recurrence. PET-alone and integrated PET/CT images were evaluated by two different experienced radiologists by consensus for each investigation. A final diagnosis was confirmed by histopathology, radiological imaging, and clinical follow-up for over 1 year. Patient-based analysis showed that the sensitivity, specificity, and accuracy of PET/CT were 92.0% (23/25), 92.6% (25/27), and 92.3% (48/52), respectively, while for PET, the corresponding figures were 80.0% (20/25), 77.8% (21/27), and 78.8% (41/52), respectively. PET/CT resolved the false-positive PET results due to hypermetabolic activity of benign/inflammatory lesions and physiological variants, and was able to detect lung metastasis, local recurrence, peritoneal dissemination, para-aortic lymph node metastasis, and pelvic lymph node metastasis missed by PET alone. However, tiny local recurrence and lymph node metastasis could not be detected even by PET/CT. FDG-PET/CT is a useful complementary modality for providing good anatomic and functional localization of sites of recurrence during follow-up of patients with cervical cancer.

Keywords

Cervical cancer Recurrence 18F-FDG PET/CT 

Notes

Acknowledgments

We thank the staff of the department of obstetrics and gynecology, especially Ichio Fukasawa and Noriyuki Inaba, for recruiting patients. We also thank Kennichi Kobayashi, Kazufumi Suzuki, Kaoru Ishida, and Tomoyuki Sakamoto for their excellent technical assistance and generous support.

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Copyright information

© European Society of Radiology 2008

Authors and Affiliations

  • Kazuhiro Kitajima
    • 1
    • 2
    • 3
    Email author
  • Koji Murakami
    • 2
  • Erena Yamasaki
    • 2
  • Yasushi Domeki
    • 2
  • Yasushi Kaji
    • 1
  • Kazuro Sugimura
    • 3
  1. 1.Departments of RadiologyDokkyo University School of MedicineShimotuka-gunJapan
  2. 2.PET CenterDokkyo Medical University HospitalMibuJapan
  3. 3.Department of RadiologyKobe University Graduate School of MedicineKobeJapan

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