European Radiology

, Volume 18, Issue 2, pp 384–389 | Cite as

Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results

  • Shinya Fujii
  • Eiji Matsusue
  • Junzo Kigawa
  • Shinya Sato
  • Yoshiko Kanasaki
  • Junko Nakanishi
  • Shuji Sugihara
  • Toshio Kaminou
  • Naoki Terakawa
  • Toshihide Ogawa


Our purpose is to evaluate the diagnostic accuracy of apparent diffusion coefficient (ADC) measurement in differentiating malignant from benign uterine endometrial cavity lesions. We retrospectively evaluated 25 uterine endometrial cavity lesions in 25 female patients: endometrial carcinoma (n = 11), carcinosarcoma (n = 2), submucosal leiomyoma (n = 8), and endometrial polyp (n = 4). Diffusion-weighted images were performed at 1.5 T with b factors of 0–1,000/mm2. The region of interest was defined within the tumor on T2-weighted EPI image and then manually copied to an ADC map. Thereby, the ADC value was obtained. We compared ADC values between malignant and benign lesions using Student’s t-test. The mean and standard deviation of ADC values (×10−3 mm2/s) were as follows: endometrial carcinoma, 0.98±0.21; carcinosarcoma, 0.97±0.02; submucosal leiomyoma, 1.37±0.28; and endometrial polyp, 1.58±0.45. The ADC values differed significantly between malignant (0.98±0.19) and benign lesions (1.44±0.34) (P < 0.01). We defined malignant tumors as cases with an ADC value less than 1.15 × 10−3 mm2/s for obtaining the highest accuracy. Sensitivity, specificity, and accuracy were 84.6%, 100%, and 92%, respectively. ADC measurement can provide useful information in differentiating malignant from benign uterine endometrial cavity lesions.


Magnetic resonance imaging Diffusion-weighted imaging Uterus Diagnostic accuracy Sensitivity Specificity 



We are grateful to Eiji Yamashita, B.S., Naoki Iwata, B.S., Takuro Tanaka, B.S., and Hiroki Katayama, B.S., for their technical support in obtaining the high-quality MR images used in this study.


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Copyright information

© European Society of Radiology 2007

Authors and Affiliations

  • Shinya Fujii
    • 1
  • Eiji Matsusue
    • 1
  • Junzo Kigawa
    • 2
  • Shinya Sato
    • 2
  • Yoshiko Kanasaki
    • 1
  • Junko Nakanishi
    • 1
  • Shuji Sugihara
    • 1
  • Toshio Kaminou
    • 1
  • Naoki Terakawa
    • 2
  • Toshihide Ogawa
    • 1
  1. 1.Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of MedicineTottori UniversityYonagoJapan
  2. 2.Division of Reproductive-Perinatal Medicine and Gynecological Oncology, Department of Surgery, Faculty of MedicineTottori UniversityYonagoJapan

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