European Radiology

, Volume 18, Issue 2, pp 308–317 | Cite as

ECG-gated chest CT angiography with 64-MDCT and tri-phasic IV contrast administration regimen in patients with acute non-specific chest pain

  • Diana LitmanovitchEmail author
  • Giulia A. Zamboni
  • Thomas H. Hauser
  • Pei-Jan P. Lin
  • Melvin E. Clouse
  • Vassilios Raptopoulos


The purpose of this study was to evaluate chest CTA protocol using retrospective ECG-gating and triphasic IV contrast regimen for comprehensive evaluation of patients with acute non-specific chest pain. ECG-triggered dose modulation was used with a 64-MDCT scanner in 56 non-critically ill patients with acute nonspecific chest pain using triphasic IV regimen: 50 ml contrast followed by 50 ml 60% contrast/saline and 30 ml normal saline. Lungs, aorta, pulmonary and coronary arteries were graded on a 5-point scale (5, best). Aorta and pulmonary artery attenuation was measured and three coronary artery groups were evaluated. Comparison with invasive coronary angiography was obtained in nine patients on a per segment (16 total) basis. Dosimetry values were obtained. Studies were satisfactory in all patients (score >3). Aorta and pulmonary artery attenuation was >200 HU in 90.5%. Lung or pleura, non-cardiac vascular and coronary arteries disease were detected in 20, 11 and 16 patients, respectively. Median coronary angiography (grade 5) was significantly higher than acceptable for diagnosis grade 4 (p < 0.001). Per segment, weighted kappa statistic was 0.79 indicating substantial agreement with catheter angiography (p<0.001). Average DLP was 1,490 ± 412 mGy-cm. Gated 64-MDCT angiography with triphasic IV contrast is a robust multipurpose technique for patients with acute non-specific chest pain.


Computed tomography Coronary arteries ECG-gated chest CT Acute chest pain Emergency department 



The authors are grateful to (Donna Wolfe) for editorial assistance and to (Clotell Forde) for secretarial, data formatting and literature search assistance and (Iryna Rastorhuyeva) for assistance with data collection.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Diana Litmanovitch
    • 1
    • 2
    Email author
  • Giulia A. Zamboni
    • 1
    • 2
  • Thomas H. Hauser
    • 2
    • 3
  • Pei-Jan P. Lin
    • 1
    • 2
  • Melvin E. Clouse
    • 1
    • 2
  • Vassilios Raptopoulos
    • 1
    • 2
  1. 1.Department of RadiologyBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA
  2. 2.Department of RadiologyHarvard Medical SchoolBostonUSA
  3. 3.Department of CardiologyBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA

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