European Radiology

, Volume 17, Issue 12, pp 3079–3085

In vivo MR tractography of thigh muscles using diffusion imaging: initial results

  • J. F. Budzik
  • V. Le Thuc
  • X. Demondion
  • M. Morel
  • D. Chechin
  • A. Cotten
Musculoskeletal

Abstract

The aims of this preliminary study were (1) to demonstrate the feasibility of providing in vivo 3D architecture of human thigh muscles using tractography on a 1.5T magnet, and (2) to assess the value of tractography images to obtain averaged microstructural parameters, i.e., the fractional anisotropy (FA) and the mean apparent diffusion coefficient (ADC), over the whole thigh. Five healthy volunteers were included in this study. Their right thighs were imaged using diffusion tensor imaging and gradient-echo T2* sequences. Muscular tractography was performed on each muscle. MR tractography provided a good approach of the muscle shape and of the orientation of the muscle fibers. There was no aberration in the color-encoding scheme nor in the luminosity assigned to each fiber. In contrast, tendons were not drawn in any of the muscles studied. FA values ranged from 0.27 to 0.38. Mean ADC values ranged from 0.76 to 0.96 × 10−3 mm2/s. Our study demonstrated the feasibility of providing in vivo 3D architecture of human thigh muscles using tractography on a 1.5T magnet, and of determining muscular microstructural parameters (FA and ADC). Musculoskeletal radiologists should be aware of these new developments that may provide complementary information on muscles to the usual sequences.

Keywords

Thigh Diffusion tensor imaging Fiber tracking Muscle MRI 

References

  1. 1.
    Basser PJ, Jones DK (2002) Diffusion-tensor MRI: theory, experimental design and data analysis - a technical review. NMR Biomed 15:456–467PubMedCrossRefGoogle Scholar
  2. 2.
    Bammer R, Acar B, Moseley ME (2003) In vivo MR tractography using diffusion imaging. Eur J Radiol 45:223–234PubMedCrossRefGoogle Scholar
  3. 3.
    Yang L, Zhang MZ, Zhang W, Zhao YL, Zhao JZ (2006) [Application of diffusion tensor imaging tractography in minimally invasive surgery of brain tumors.] Zhonghua Yi Xue Za Zhi 86:1301–1304PubMedGoogle Scholar
  4. 4.
    van Doorn A, Bovendeerd PH, Nicolay K, Drost MR, Janssen JD (1996) Determination of muscle fibre orientation using diffusion-weighted MRI. Eur J Morphol 34:5–10PubMedCrossRefGoogle Scholar
  5. 5.
    Heemskerk AM, Strijkers GJ, Vilanova A, Drost MR, Nicolay K (2005) Determination of mouse skeletal muscle architecture using three-dimensional diffusion tensor imaging. Magn Reson Med 53:1333–1340PubMedCrossRefGoogle Scholar
  6. 6.
    Damon BM, Ding Z, Anderson AW, Freyer AS, Gore JC (2002) Validation of diffusion tensor MRI-based muscle fiber tracking. Magn Reson Med 48:97–104PubMedCrossRefGoogle Scholar
  7. 7.
    Galban CJ, Maderwald S, Uffmann K, de Greiff A, Ladd ME (2004) Diffusive sensitivity to muscle architecture: a magnetic resonance diffusion tensor imaging study of the human calf. Eur J Appl Physiol 253–262Google Scholar
  8. 8.
    Sinha S, Sinha U, Edgerton VR (2006) In vivo diffusion tensor imaging of the human calf muscle. J Magn Reson Imaging 24:182–190PubMedCrossRefGoogle Scholar
  9. 9.
    Galban CJ, Maderwald S, Uffmann K, Ladd ME (2005) A diffusion tensor imaging analysis of gender differences in water diffusivity within human skeletal muscle. NMR Biomed 18:489–498PubMedCrossRefGoogle Scholar
  10. 10.
    Zaraiskaya T, Kumbhare D, Noseworthy MD (2006) Diffusion tensor imaging in evaluation of human skeletal muscle injury. J Magn Reson Imaging 24:402–408PubMedCrossRefGoogle Scholar
  11. 11.
    Jellison BJ, Field AS, Medow J, Lazar M, Salamat MS, Alexander AL (2004) Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. Am J Neuroradiol 25:356–369PubMedGoogle Scholar
  12. 12.
    Mori S, Crain BJ, Chacko VP, van Zijl PC (1999) Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 45:265–269PubMedCrossRefGoogle Scholar
  13. 13.
    Price RR, Morgan T, Newman R et al (1990) Quality assurance methods and phantoms for magnetic resonance imaging: report of AAPM Nuclear Imaging Resonance Task Group No. 1. Med Phys 17:287–295PubMedCrossRefGoogle Scholar
  14. 14.
    Sinha U, Yao L (2002) In vivo diffusion tensor imaging of human calf muscle. J Magn Reson Imaging 15:87–95PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • J. F. Budzik
    • 1
  • V. Le Thuc
    • 1
  • X. Demondion
    • 1
    • 2
  • M. Morel
    • 1
  • D. Chechin
    • 3
  • A. Cotten
    • 1
  1. 1.Service de Radiologie OstéoarticulaireHôpital Roger Salengro, CHRU de LilleLille CedexFrance
  2. 2.Laboratoire d’AnatomieFaculté de Médecine de LilleLilleFrance
  3. 3.Philips Medical SystemsSuresnesFrance

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