European Radiology

, Volume 17, Issue 7, pp 1865–1874 | Cite as

Early mammographic and sonographic findings after intraoperative radiotherapy (IORT) as a boost in patients with breast cancer

  • K. Wasser
  • C. Schoeber
  • U. Kraus-Tiefenbacher
  • L. Bauer
  • J. Brade
  • J. Teubner
  • F. Wenz
  • W. Neff


The aim of this study was to evaluate mammographic and sonographic changes at the surgical site within the first 2 years after IORT as a boost followed by whole-breast radiotherapy (WBRT), compared with a control group treated with WBRT alone. All patients had breast-conserving surgery for early-stage breast cancer. Group A: n = 27, IORT (20 Gy) followed by WBRT (46 Gy). Group B (control group): n = 27, WBRT alone (56–66 Gy). Mammography: fat necrosis in 14 group A versus four group B patients (P < 0.001); parenchymal scarring classified as unorganized at the last follow-up in 16 vs seven cases, respectively (P = 0.03). Ultrasound: overall number of patients with circumscribed findings 27 vs 18 (P < 0.001); particular hematomas/seromas in 26 vs 13 patients (P < 0.001). Synopsis of mammography and ultrasound: overall postoperative changes were significantly higher classified in group A (P = 0.01), but not judged to have a significantly higher impact on interpretation. Additional diagnostic procedures, due to unclear findings at the surgical site, were performed on four patients of both groups. Within the first 2 years after IORT as a boost, therapy-induced changes at the original tumor site are significantly more pronounced compared with a control group. There is no evidence that the interpretation of findings is complicated after IORT.


Mammography Ultrasound Breast cancer Intraoperative radiotherapy 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • K. Wasser
    • 1
  • C. Schoeber
    • 1
  • U. Kraus-Tiefenbacher
    • 2
  • L. Bauer
    • 3
  • J. Brade
    • 4
  • J. Teubner
    • 1
    • 5
  • F. Wenz
    • 2
  • W. Neff
    • 1
  1. 1.Department of RadiologyUniversity Hospital Mannheim, University of HeidelbergHeidelbergGermany
  2. 2.Department of Radiation Oncology, Mannheim Medical CenterUniversity of HeidelbergHeidelbergGermany
  3. 3.Department of Gynecology and ObstetricsUniversity Hospital Mannheim, University of HeidelbergHeidelbergGermany
  4. 4.Department of StatisticsUniversity Hospital Mannheim, University of HeidelbergHeidelbergGermany
  5. 5.Diagnostic Breastcenter St. Elisabethklinik HeidelbergHeidelbergGermany

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