Contrast-enhanced 3D MRI of lung perfusion in children with cystic fibrosis—initial results
- 436 Downloads
This paper is a feasibility study of magnetic resonance imaging (MRI) of lung perfusion in children with cystic fibrosis (CF) using contrast-enhanced 3D MRI. Correlation assessment of perfusion changes with structural abnormalities. Eleven CF patients (9 f, 2 m; median age 16 years) were examined at 1.5 T. Morphology: HASTE coronal, transversal (TR/TE/α/ST: 600 ms/28 ms/180°/6 mm), breath-hold 18 s. Perfusion: Time-resolved 3D GRE pulse sequence (FLASH, TE/TR/α: 0.8/1.9 ms/40°), parallel imaging (GRAPPA, PAT 2). Twenty-five data sets were acquired after intravenous injection of 0.1 mmol/kg body weight of gadodiamide, 3–5 ml/s. A total of 198 lung segments were analyzed by two radiologists in consensus and scored for morphological and perfusion changes. Statistical analysis was performed by Mantel-Haenszel chi-square test. Results showed that perfusion defects were observed in all patients and present in 80% of upper, and 39% of lower lobes. Normal lung parenchyma showed homogeneous perfusion (86%, P<0.0001). Severe morphological changes led to perfusion defects (97%, P<0.0001). Segments with moderate morphological changes showed normal (53%) or impaired perfusion (47%). In conclusion, pulmonary perfusion is easy to judge in segments with normal parenchyma or severe changes. In moderately damaged segments, MRI of lung perfusion may help to better assess actual functional impairment. Contrast-enhanced 3D MRI of lung perfusion has the potential for early vascular functional assessment and therapy control in CF patients.
KeywordsCystic fibrosis MRI Lung perfusion Lung morphology
This study was supported by Forschungsgemeinschaft Mukoviszidose (Mukoviszidose e.V.): S06/04.
- 12.Puderbach M, Eichinger M, Ley S, Fink C, Plathow C, Gahr J, Wiebel M, Tuengerthal S, Schmahl A, Mueller FM, Kauczor HU (2004) Visualisation of parenchymal lung changes in patients with cystic fibrosis (CF) - MRI versus HRCT. J Cyst Fibros 3(Suppl 1):54Google Scholar
- 13.Stern M, Sens B, Wiedermann B, Busse O, Damm G, Wenzlaff P (2005) Qualitätssicherung Mukoviszidose, Überblick über den Gesundheitszustand der Patienten in Deutschland 2004. Verlag Wissenschaftliche Scripten, ZwickauGoogle Scholar
- 24.Abolmaali N, Schmidt H, Anjorin A, Posselt H-G, Vogl TJ (2002) Chrispin-Norman-score and Bhalla-score of patients with cystic fibrosis: Comparative study of chest radiographs and MR-Imaging. Eur Radiol 12 [Congress Suppl]:227Google Scholar