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European Radiology

, Volume 16, Issue 10, pp 2147–2152 | Cite as

Contrast-enhanced 3D MRI of lung perfusion in children with cystic fibrosis—initial results

  • Monika EichingerEmail author
  • Michael Puderbach
  • Christian Fink
  • Julie Gahr
  • Sebastian Ley
  • Christian Plathow
  • Siegfried Tuengerthal
  • Ivan Zuna
  • Frank-Michael Müller
  • Hans-Ulrich Kauczor
Chest

Abstract

This paper is a feasibility study of magnetic resonance imaging (MRI) of lung perfusion in children with cystic fibrosis (CF) using contrast-enhanced 3D MRI. Correlation assessment of perfusion changes with structural abnormalities. Eleven CF patients (9 f, 2 m; median age 16 years) were examined at 1.5 T. Morphology: HASTE coronal, transversal (TR/TE/α/ST: 600 ms/28 ms/180°/6 mm), breath-hold 18 s. Perfusion: Time-resolved 3D GRE pulse sequence (FLASH, TE/TR/α: 0.8/1.9 ms/40°), parallel imaging (GRAPPA, PAT 2). Twenty-five data sets were acquired after intravenous injection of 0.1 mmol/kg body weight of gadodiamide, 3–5 ml/s. A total of 198 lung segments were analyzed by two radiologists in consensus and scored for morphological and perfusion changes. Statistical analysis was performed by Mantel-Haenszel chi-square test. Results showed that perfusion defects were observed in all patients and present in 80% of upper, and 39% of lower lobes. Normal lung parenchyma showed homogeneous perfusion (86%, P<0.0001). Severe morphological changes led to perfusion defects (97%, P<0.0001). Segments with moderate morphological changes showed normal (53%) or impaired perfusion (47%). In conclusion, pulmonary perfusion is easy to judge in segments with normal parenchyma or severe changes. In moderately damaged segments, MRI of lung perfusion may help to better assess actual functional impairment. Contrast-enhanced 3D MRI of lung perfusion has the potential for early vascular functional assessment and therapy control in CF patients.

Keywords

Cystic fibrosis MRI Lung perfusion Lung morphology 

Notes

Acknowledgement

This study was supported by Forschungsgemeinschaft Mukoviszidose (Mukoviszidose e.V.): S06/04.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Monika Eichinger
    • 1
    Email author
  • Michael Puderbach
    • 1
  • Christian Fink
    • 2
  • Julie Gahr
    • 3
  • Sebastian Ley
    • 1
    • 4
  • Christian Plathow
    • 5
  • Siegfried Tuengerthal
    • 6
  • Ivan Zuna
    • 1
  • Frank-Michael Müller
    • 3
  • Hans-Ulrich Kauczor
    • 1
  1. 1.Department of Radiology (E010)Deutsches Krebsforschungszentrum (DKFZ)HeidelbergGermany
  2. 2.Department of RadiologyInstitut für Klinische Radiologie, Klinikum der LMU GroßhadernMünchenGermany
  3. 3.Department of Pediatric Pulmonology, Cystic Fibrosis Centre and Infectious DiseasesUniversitätskinderklinik III HeidelbergHeidelbergGermany
  4. 4.Department of Pediatric RadiologyUniversitätskinderklinik HeidelbergHeidelbergGermany
  5. 5.Department of Diagnostic RadiologyEberhard-Karls UniversityTuebingenGermany
  6. 6.Department of RadiologyThoraxklinik am Universitätsklinikum HeidelbergHeidelbergGermany

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