Advertisement

European Radiology

, Volume 16, Issue 9, pp 1898–1905 | Cite as

Colorectal hepatic metastases: quantitative measurements using single-shot echo-planar diffusion-weighted MR imaging

  • D. M. KohEmail author
  • E. Scurr
  • D. J. Collins
  • A. Pirgon
  • B. Kanber
  • N. Karanjia
  • G. Brown
  • M. O. Leach
  • J. E. Husband
Hepatobiliary-Pancreas

Abstract

The purpose of this study was to obtain quantitative measurements of the apparent diffusion coefficient (ADC1), flow insensitive apparent diffusion coefficient (ADC2) and perfusion fraction (F) of colorectal hepatic metastases using DWI and to compare these measurements with those obtained in liver parenchyma. Forty patients with 66 hepatic metastases from colorectal carcinoma were prospectively evaluated using DWI with three b values. Quantitative maps of the ADC1 (using b=0, 150, 500 s/mm2images), ADC2 (using b=150, 500 s/mm2 images) and fractional variation (F) between ADC1 and ADC2, which reflects perfusion fraction, were calculated. The ADC1, ADC2 and F derived from metastases and liver parenchyma were compared. The mean ADC1 values of liver parenchyma and metastases were significantly higher than the mean ADC2 values (P<0.0001, paired t-test). Colorectal metastases were found to have higher mean ADC1 and ADC2 values compared with liver (P<0.0001, Mann-Whitney test). However, the estimated F was found to be lower in metastases compared to liver (P=0.03, Mann-Whitney test). Colorectal hepatic metastases were characterised by higher ADC1 and ADC2 values, but lower F values compared to liver.

Keywords

Colorectal Diffusion MR imaging Metastasis 

Notes

Acknowledgement

This work is supported by Cancer Research UK Grant number C1060/A5117.

References

  1. 1.
    Yamashita Y, Tang Y, Takahashi M (1998) Ultrafast MR imaging of the abdomen: echo planar imaging and diffusion-weighted imaging. J Magn Reson Imaging 8:367–374PubMedCrossRefGoogle Scholar
  2. 2.
    Ito K, Mitchell DG, Matsunaga N (1999) MR imaging of the liver: techniques and clinical applications. Eur J Radiol 32:2–14PubMedCrossRefGoogle Scholar
  3. 3.
    Okada Y, Ohtomo K, Kiryu S, Sasaki Y (1998) Breath-hold T2-weighted MRI of hepatic tumors: value of echo planar imaging with diffusion-sensitizing gradient. J Comput Assist Tomogr 22:364–371PubMedCrossRefGoogle Scholar
  4. 4.
    Taouli B, Vilgrain V, Dumont E, Daire JL, Fan B, Menu Y (2003) Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients. Radiology 226:71–78PubMedCrossRefGoogle Scholar
  5. 5.
    Nasu K (2003) Evaluation of hepatic metastasis on SENSE-DWI: comparison with SPIO-MRI. Chicago 363Google Scholar
  6. 6.
    Yamada I, Aung W, Himeno Y, Nakagawa T, Shibuya H (1999) Diffusion coefficients in abdominal organs and hepatic lesions: evaluation with intravoxel incoherent motion echo-planar MR imaging. Radiology 210:617–623PubMedGoogle Scholar
  7. 7.
    Namimoto T, Yamashita Y, Sumi S, Tang Y, Takahashi M (1997) Focal liver masses: characterization with diffusion-weighted echo-planar MR imaging. Radiology 204:739–744PubMedGoogle Scholar
  8. 8.
    Delakis I, Moore EM, Leach MO, De Wilde JP (2004) Developing a quality control protocol for diffusion imaging on a clinical MRI system. Phys Med Biol 49:1409–1422PubMedCrossRefGoogle Scholar
  9. 9.
    Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505PubMedGoogle Scholar
  10. 10.
    Kim YK, Lee JM, Kim CS, Chung GH, Kim CY, Kim IH (2005) Detection of liver metastases: gadobenate dimeglumine-enhanced three-dimensional dynamic phases and one-hour delayed phase MR imaging versus superparamagnetic iron oxide-enhanced MR imaging. Eur Radiol 15:220–228PubMedCrossRefGoogle Scholar
  11. 11.
    Roth Y, Tichler T, Kostenich G et al (2004) High-b-value diffusion-weighted MR imaging for pretreatment prediction and early monitoring of tumor response to therapy in mice. Radiology 232:685–692PubMedCrossRefGoogle Scholar
  12. 12.
    Thoeny HC, De Keyzer F, Chen F et al (2005) Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats. Radiology 234:756–764PubMedCrossRefGoogle Scholar
  13. 13.
    Thoeny HC, De Keyzer F, Vandecaveye V et al (2005) Effect of vascular targeting agent in rat tumor model: dynamic contrast-enhanced versus diffusion-weighted MR imaging. Radiology 237:492–499PubMedCrossRefGoogle Scholar
  14. 14.
    Brauer M (2003) In vivo monitoring of apoptosis. Prog Neuropsychopharmacol Biol Psychiatry 27:323–331PubMedCrossRefGoogle Scholar
  15. 15.
    Murtz P, Flacke S, Traber F, van den Brink JS, Gieseke J, Schild HH (2002) Abdomen: diffusion-weighted MR imaging with pulse-triggered single-shot sequences. Radiology 224:258–264PubMedCrossRefGoogle Scholar
  16. 16.
    Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T (1998) Diffusion-weighted MR imaging with a single-shot echoplanar sequence: detection and characterization of focal hepatic lesions. AJR Am J Roentgenol 170:397–402PubMedGoogle Scholar
  17. 17.
    Muller MF, Prasad P, Siewert B, Nissenbaum MA, Raptopoulos V, Edelman RR (1994) Abdominal diffusion mapping with use of a whole-body echo-planar system. Radiology 190:475–478PubMedGoogle Scholar
  18. 18.
    Kim T, Murakami T, Takahashi S, Hori M, Tsuda K, Nakamura H (1999) Diffusion-weighted single-shot echoplanar MR imaging for liver disease. AJR Am J Roentgenol 173:393–398PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • D. M. Koh
    • 1
    • 2
    Email author
  • E. Scurr
    • 2
  • D. J. Collins
    • 1
  • A. Pirgon
    • 1
  • B. Kanber
    • 1
  • N. Karanjia
    • 3
  • G. Brown
    • 1
  • M. O. Leach
    • 1
  • J. E. Husband
    • 1
    • 2
  1. 1.Cancer Research UK Magnetic Resonance Clinical Research GroupInstitute of Cancer ResearchSuttonUK
  2. 2.Academic Department of RadiologyRoyal Marsden HospitalSuttonUK
  3. 3.Department of SurgeryRoyal Surrey County HospitalGuildfordUK

Personalised recommendations