The purpose of this study was to obtain quantitative measurements of the apparent diffusion coefficient (ADC1), flow insensitive apparent diffusion coefficient (ADC2) and perfusion fraction (F) of colorectal hepatic metastases using DWI and to compare these measurements with those obtained in liver parenchyma. Forty patients with 66 hepatic metastases from colorectal carcinoma were prospectively evaluated using DWI with three b values. Quantitative maps of the ADC1 (using b=0, 150, 500 s/mm2images), ADC2 (using b=150, 500 s/mm2 images) and fractional variation (F) between ADC1 and ADC2, which reflects perfusion fraction, were calculated. The ADC1, ADC2 and F derived from metastases and liver parenchyma were compared. The mean ADC1 values of liver parenchyma and metastases were significantly higher than the mean ADC2 values (P<0.0001, paired t-test). Colorectal metastases were found to have higher mean ADC1 and ADC2 values compared with liver (P<0.0001, Mann-Whitney test). However, the estimated F was found to be lower in metastases compared to liver (P=0.03, Mann-Whitney test). Colorectal hepatic metastases were characterised by higher ADC1 and ADC2 values, but lower F values compared to liver.
Colorectal Diffusion MR imaging Metastasis
This is a preview of subscription content, log in to check access.
This work is supported by Cancer Research UK Grant number C1060/A5117.
Yamashita Y, Tang Y, Takahashi M (1998) Ultrafast MR imaging of the abdomen: echo planar imaging and diffusion-weighted imaging. J Magn Reson Imaging 8:367–374PubMedCrossRefGoogle Scholar
Ito K, Mitchell DG, Matsunaga N (1999) MR imaging of the liver: techniques and clinical applications. Eur J Radiol 32:2–14PubMedCrossRefGoogle Scholar
Okada Y, Ohtomo K, Kiryu S, Sasaki Y (1998) Breath-hold T2-weighted MRI of hepatic tumors: value of echo planar imaging with diffusion-sensitizing gradient. J Comput Assist Tomogr 22:364–371PubMedCrossRefGoogle Scholar
Taouli B, Vilgrain V, Dumont E, Daire JL, Fan B, Menu Y (2003) Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients. Radiology 226:71–78PubMedCrossRefGoogle Scholar
Nasu K (2003) Evaluation of hepatic metastasis on SENSE-DWI: comparison with SPIO-MRI. Chicago 363Google Scholar
Yamada I, Aung W, Himeno Y, Nakagawa T, Shibuya H (1999) Diffusion coefficients in abdominal organs and hepatic lesions: evaluation with intravoxel incoherent motion echo-planar MR imaging. Radiology 210:617–623PubMedGoogle Scholar
Namimoto T, Yamashita Y, Sumi S, Tang Y, Takahashi M (1997) Focal liver masses: characterization with diffusion-weighted echo-planar MR imaging. Radiology 204:739–744PubMedGoogle Scholar
Delakis I, Moore EM, Leach MO, De Wilde JP (2004) Developing a quality control protocol for diffusion imaging on a clinical MRI system. Phys Med Biol 49:1409–1422PubMedCrossRefGoogle Scholar
Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M (1988) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168:497–505PubMedGoogle Scholar
Kim YK, Lee JM, Kim CS, Chung GH, Kim CY, Kim IH (2005) Detection of liver metastases: gadobenate dimeglumine-enhanced three-dimensional dynamic phases and one-hour delayed phase MR imaging versus superparamagnetic iron oxide-enhanced MR imaging. Eur Radiol 15:220–228PubMedCrossRefGoogle Scholar
Roth Y, Tichler T, Kostenich G et al (2004) High-b-value diffusion-weighted MR imaging for pretreatment prediction and early monitoring of tumor response to therapy in mice. Radiology 232:685–692PubMedCrossRefGoogle Scholar
Thoeny HC, De Keyzer F, Chen F et al (2005) Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats. Radiology 234:756–764PubMedCrossRefGoogle Scholar
Thoeny HC, De Keyzer F, Vandecaveye V et al (2005) Effect of vascular targeting agent in rat tumor model: dynamic contrast-enhanced versus diffusion-weighted MR imaging. Radiology 237:492–499PubMedCrossRefGoogle Scholar