European Radiology

, Volume 15, Issue 8, pp 1544–1549 | Cite as

CT volumetry of intravertebral cement after kyphoplasty. Comparison of polymethylmethacrylate and calcium phosphate in a 12-month follow-up

  • M. Libicher
  • M. Vetter
  • I. Wolf
  • G. Noeldge
  • C. Kasperk
  • I. Grafe
  • K. Da Fonseca
  • J. Hillmeier
  • P. J. Meeder
  • H. P. Meinzer
  • G. W. Kauffmann


This study was intended to measure the volume of intravertebral cement after balloon kyphoplasty with high resolution computed tomography (CT) and dedicated software. Volume changes of biocompatible calcium phosphate cement (CPC) were detected during a follow-up of 12 months. Measurements were compared with a control group of patients treated with polymethylmethacrylate (PMMA). Twenty-three vertebrae (14 CPC, 9 PMMA) of 12 patients were examined with CT using an identical imaging protocol. Dedicated software was used to quantify intravertebral cement volume in subvoxel resolution by analyzing each cement implant with a density-weighted algorithm. The mean volume reduction of CPC was 0.08 ml after 12 months, which corresponds to an absorption rate of 2 vol%. However, the difference did not reach significance level (P>0.05). The mean error estimate was 0.005 ml, indicating excellent precision of the method. CT volumetry appears a precise tool for measurement of intravertebral cement volume. CT volumetry offers the possibility of in vivo measurement of CPC resorption.


Polymethylmethacrylate cement Vertebroplasty Kyphoplasty Compression fracture Calcium phosphate cement 


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • M. Libicher
    • 1
  • M. Vetter
    • 2
  • I. Wolf
    • 2
  • G. Noeldge
    • 1
  • C. Kasperk
    • 3
  • I. Grafe
    • 3
  • K. Da Fonseca
    • 4
  • J. Hillmeier
    • 5
  • P. J. Meeder
    • 4
  • H. P. Meinzer
    • 2
  • G. W. Kauffmann
    • 1
  1. 1.Department of Diagnostic RadiologyUniversity of HeidelbergHeidelbergGermany
  2. 2.Departments of Medical and Biological InformaticsDeutsches KrebsforschungszentrumHeidelbergGermany
  3. 3.Department of Internal MedicineUniversity of HeidelbergHeidelbergGermany
  4. 4.Department of Trauma SurgeryUniversity of HeidelbergHeidelbergGermany
  5. 5.Department of Trauma SurgerySt Vincenz HospitalLimburgGermany

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