European Radiology

, Volume 16, Issue 5, pp 1090–1095 | Cite as

Diffusion-weighted MR imaging in transient ischaemic attacks

  • C. Lamy
  • C. Oppenheim
  • D. Calvet
  • V. Domigo
  • O. Naggara
  • JL Méder
  • JL Mas
Neuro

Abstract

The purpose of this study was to determine frequency and the characteristics of diffusion-weighted imaging (DWI) abnormalities in patients with transient ischaemic attack (TIA). We analysed data of 98 consecutive patients (mean age: 60.6±15.4 years, 56 men) admitted between January 2003 and April 2004 for TIA. Age, gender, symptom type and duration, delay from onset to magnetic resonance imaging (MRI), probable or possible TIA and cause of TIA were compared in patients with (DWI+) and without (DWI−) lesions on DWI. Volume and apparent diffusion coefficient (ADC) values of DWI lesions were computed. DWI revealed ischaemic lesions in 34 patients (34.7%). Lesions were small (mean volume: 1.9 cm3±3.3), and ADC was moderately decreased (mean ADC ratio: 79.5%). The diagnosis of TIA was considered as probable in all DWI+ patients. A multiple logistic regression model demonstrated that TIA duration greater than or equal to 60 min (OR, 7.6; 95% CI, 2.3–25.7), aphasia (OR, 9.2; 95% CI, 2.7–31.4) and motor deficit (OR, 5.1; 95% CI, 1.5–17.8) were independent predictors of DWI lesions. Prolonged TIA duration, aphasia and motor deficits are associated with DWI lesions. More than half of TIA patients with symptoms lasting more than 60 min have DWI lesions.

Keywords

Ischaemic attack Transient magnetic resonance imaging Diffusion-weighted-Cerebral ischemia 

References

  1. 1.
    Special report from the National Institute of Neurological Disorders and Stroke (1990) Classification of cerebrovascular diseases III. Stroke 21:637–676Google Scholar
  2. 2.
    Gass A, Ay H, Szabo K, Koroshetz WJ (2004) Diffusion-weighted MRI for the "small stuff": the details of acute cerebral ischaemia. Lancet Neurol 3:39–45CrossRefPubMedGoogle Scholar
  3. 3.
    Warach S, Kidwell CS (2004) The redefinition of TIA: the uses and limitations of DWI in acute ischemic cerebrovascular syndromes. Neurology 62:359–360PubMedGoogle Scholar
  4. 4.
    Awad I, Modic M, Little JR, Furlan AJ, Weinstein M (1986) Focal parenchymal lesions in transient ischemic attacks: correlation of computed tomography and magnetic resonance imaging. Stroke 17:399–403PubMedGoogle Scholar
  5. 5.
    Bogousslavsky J, Regli F (1985) Cerebral infarct in apparent transient ischemic attack. Neurology 35:1501–1503PubMedGoogle Scholar
  6. 6.
    Davalos A, Matias–Guiu J, Torrent O, Vilaseca J, Codina A (1988) Computed tomography in reversible ischaemic attacks: clinical and prognostic correlations in a prospective study. J Neurol 235:155–158CrossRefPubMedGoogle Scholar
  7. 7.
    Dennis M, Bamford J, Sandercock P, Molyneux A, Warlow C (1990) Computed tomography in patients with transient ischaemic attacks: when is a transient ischaemic attack not a transient ischaemic attack but a stroke? J Neurol 237:257–261CrossRefPubMedGoogle Scholar
  8. 8.
    Evans GW, Howard G, Murros KE, Rose LA, Toole JF (1991) Cerebral infarction verified by cranial computed tomography and prognosis for survival following transient ischemic attack. Stroke 22:431–436PubMedGoogle Scholar
  9. 9.
    Koudstaal PJ, van Gijn J, Frenken CW, Hijdra A, Lodder J, Vermeulen M, Bulens C, Franke CL (1992) TIA, RIND, minor stroke: a continuum, or different subgroups? Dutch TIA Study Group. J Neurol Neurosurg Psychiatry 55:95–97PubMedCrossRefGoogle Scholar
  10. 10.
    Fazekas F, Fazekas G, Schmidt R, Kapeller P, Offenbacher H (1996) Magnetic resonance imaging correlates of transient cerebral ischemic attacks. Stroke 27:607–611PubMedGoogle Scholar
  11. 11.
    Kimura K, Minematsu K, Wada K, Yonemura K, Yasaka M, Yamaguchi T (2000) Lesions visualized by contrast-enhanced magnetic resonance imaging in transient ischemic attacks. J Neurol Sci 173:103–108CrossRefPubMedGoogle Scholar
  12. 12.
    Thurnher MM. Castillo M (2005) Imaging in acute stroke. Eur Radiol 15:408–415CrossRefPubMedGoogle Scholar
  13. 13.
    Ay H, Oliveira-Filho J, Buonanno FS, Schaefer PW, Furie KL, Chang YC, Rordorf G, Schwamm LH, Gonzalez RG, Koroshetz WJ (2002) ‘Footprints’ of transient ischemic attacks: a diffusion-weighted MRI study. Cerebrovasc Dis 14:177–186CrossRefPubMedGoogle Scholar
  14. 14.
    Crisostomo RA, Garcia MM, Tong DC (2003) Detection of diffusion-weighted MRI abnormalities in patients with transient ischemic attack: correlation with clinical characteristics. Stroke 34:932–937CrossRefPubMedGoogle Scholar
  15. 15.
    Engelter ST, Provenzale JM, Petrella JR, Alberts MJ (1999) Diffusion MR imaging and transient ischemic attacks. Stroke 30:2762–2763PubMedGoogle Scholar
  16. 16.
    Inatomi Y, Kimura K, Yonehara T, Fujioka S, Uchino M (2004) DWI abnormalities and clinical characteristics in TIA patients. Neurology 62:376–380PubMedGoogle Scholar
  17. 17.
    Kamal AK, Segal AZ, Ulug AM (2002) Quantitative diffusion-weighted MR imaging in transient ischemic attacks. AJNR Am J Neuroradiol 23:1533–1538PubMedGoogle Scholar
  18. 18.
    Kidwell CS, Alger JR, Di Salle F, Starkman S, Villablanca P, Bentson J, Saver JL (1999) Diffusion MRI in patients with transient ischemic attacks. Stroke 30:1174–1180PubMedGoogle Scholar
  19. 19.
    Rovira A, Rovira-Gols A, Pedraza S, Grive E, Molina C, Alvarez-Sabin J (2002) Diffusion-weighted MR imaging in the acute phase of transient ischemic attacks. AJNR Am J Neuroradiol 23:77–83PubMedGoogle Scholar
  20. 20.
    Winbeck K, Bruckmaier K, Etgen T, von Einsiedel HG, Rottinger M, Sander D (2004) Transient ischemic attack and stroke can be differentiated by analyzing early diffusion-weighted imaging signal intensity changes. Stroke 35:1095–1099CrossRefPubMedGoogle Scholar
  21. 21.
    Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE, for the TOAST Investigators (1993) Classification of subtypes of acute ischemic stroke. Definition for use in multicenter clinical trial. Stroke 24:35–41.PubMedGoogle Scholar
  22. 22.
    Rovira A, Grive E, Rovira A, Alvarez-Sabin J (2005) Distribution territories and causative mechanisms of ischemic stroke. Eur Radiol 15:416–426CrossRefPubMedGoogle Scholar
  23. 23.
    Steens SC, Admiraal-Behloul F, Schaap JA, Hoogenraad FG, Wheeler-Kingshott CA, le Cessie S, Tofts PS, van Buchem MA (2004) Reproducibility of brain ADC histograms. Eur Radiol 14:425–430CrossRefPubMedGoogle Scholar
  24. 24.
    Oppenheim C, Grandin C, Samson Y, Smith A, Duprez T, Marsault C, Cosnard G (2001) Is there an apparent diffusion coefficient threshold in predicting tissue viability in hyperacute stroke? Stroke 32:2486–2491PubMedCrossRefGoogle Scholar
  25. 25.
    Ulug AM, Beauchamp N Jr, Bryan RN, van Zijl PC (1997) Absolute quantitation of diffusion constants in human stroke. Stroke 28:483–490PubMedGoogle Scholar
  26. 26.
    Burdette JH, Ricci PE, Petitti N, Elster AD (1998) Cerebral infarction: time course of signal intensity changes on diffusion-weighted MR images. AJR Am J Roentgenol 171:791–795PubMedGoogle Scholar
  27. 27.
    Schulz UG, Briley D, Meagher T, Molyneux A, Rothwell PM (2004) Diffusion-weighted MRI in 300 patients presenting late with subacute transient ischemic attack or minor stroke. Stroke 35:2459–2465CrossRefPubMedGoogle Scholar
  28. 28.
    Albers GW, Caplan LR, Easton JD, Fayad PB, Mohr JP, Saver JL, Sherman DG (2002) Transient ischemic attack-proposal for a new definition. N Engl J Med 347:1713–1716CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • C. Lamy
    • 1
  • C. Oppenheim
    • 2
  • D. Calvet
    • 1
  • V. Domigo
    • 1
  • O. Naggara
    • 2
  • JL Méder
    • 2
  • JL Mas
    • 1
  1. 1.Service de Neurologiede l’ Hôpital Sainte-AnneParis Cedex 14France
  2. 2.Département d’ Imagere Morphologique et FonchonnilleHöpital Sainte-AnneParisFrance

Personalised recommendations