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European Radiology

, Volume 16, Issue 3, pp 575–582 | Cite as

Diagnostic accuracy of non-invasive 64-slice CT coronary angiography in patients with stable angina pectoris

  • Francesca Pugliese
  • Nico R. A. Mollet
  • Giuseppe Runza
  • Carlos van Mieghem
  • Willem B. Meijboom
  • Patrizia Malagutti
  • Timo Baks
  • Gabriel P. Krestin
  • Pim J. deFeyter
  • Filippo Cademartiri
Cardiac

Abstract

Multislice computed tomography (CT) is an emerging technique for the non-invasive detection of coronary stenoses. While the diagnostic accuracy of 4-slice scanners was limited, 16-slice CT imagers showed promising results due to increased temporal and spatial resolution. These technical advances prompted us to evaluate the diagnostic performance of 64-slice CT coronary angiography in the detection of significant stenoses (defined as ≥ 50% luminal diameter reduction) versus invasive quantitative coronary angiography (QCA). Thirty-five patients with stable angina pectoris underwent CT coronary angiography performed with a 64-slice scanner (gantry rotation time 330 ms, individual detector width 0.6 mm) prior to conventional coronary angiography. Patients with heart rates >70 beats/min received 100 mg metoprolol orally. One hundred millilitres of contrast agent with an iodine concentration of 400 mgl/ml were injected at a rate of 5 ml/s into the antecubital vein. The CT scan was triggered with the bolus tracking technique. The sensitivity, specificity and the positive and negative predictive values of 64-slice CT were 99%, 96%, 78% and 99%, respectively, on a per-segment basis. The values obtained on a per-patient basis were 100%, 90%, 96% and 100%, respectively. When referral to catheterisation is questionable, CT coronary angiography may identify subjects with normal angiograms and consistently decrease the number of unnecessary invasive procedures.

Keywords

Spiral volumetric computed tomography Coronary heart disease Coronary angiography 

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Francesca Pugliese
    • 1
  • Nico R. A. Mollet
    • 1
    • 2
  • Giuseppe Runza
    • 3
    • 4
  • Carlos van Mieghem
    • 2
  • Willem B. Meijboom
    • 2
  • Patrizia Malagutti
    • 2
    • 5
  • Timo Baks
    • 2
  • Gabriel P. Krestin
    • 1
  • Pim J. deFeyter
    • 1
    • 2
  • Filippo Cademartiri
    • 1
    • 4
  1. 1.Department of RadiologyErasmus Medical CenterRotterdamThe Netherlands
  2. 2.Department of CardiologyErasmus Medical CenterRotterdamThe Netherlands
  3. 3.Department of RadiologyUniversity of PalermoPalermoItaly
  4. 4.Department of RadiologyAzienda Ospedaliera di ParmaParmaItaly
  5. 5.Department of CardiologyUniversity of FerraraFerraraItaly

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