European Radiology

, Volume 15, Issue 2, pp 319–323 | Cite as

Noninvasive measurements of cardiac high-energy phosphate metabolites in dilated cardiomyopathy by using 31P spectroscopic chemical shift imaging

  • A. Hansch
  • R. Rzanny
  • J.-P. Heyne
  • U. Leder
  • J. R. Reichenbach
  • W. A. Kaiser


Dilated cardiomyopathy (DCM) is accompanied by an impaired cardiac energy metabolism. The aim of this study was to investigate metabolic ratios in patients with DCM compared to controls by using spectroscopic two-dimensional chemical shift imaging (2D-CSI). Twenty volunteers and 15 patients with severe symptoms (left ventricular ejection fraction, LVEF<30%) and ten patients with moderate symptoms (LVEF>30%) of DCM were investigated. Cardiac 31P MR 2D-CSI measurements (voxel size: 40×40×100 mm3) were performed with a 1.5 T whole-body scanner. Measurement time ranged from 15 min to 30 min. Peak areas and ratios of different metabolites were evaluated, including high-energy phosphates (PCr, ATP), 2,3-diphosphoglycerate (2,3-DPG) and phosphodiesters (PDE). In addition, we evaluated how PCr/ATP ratios correlate with LVEF as an established prognostic factor of heart failure. The PCr/γ-ATP ratio was significantly decreased in patients with moderate and severe DCM and showed a linear correlation with reduced LVEFs. PDE/ATP ratios were significantly increased only in patients with severe DCM as compared to volunteers. Applying 31P MRS with commonly-available 2D-CSI sequences is a valuable technique to evaluate DCM by determining PCr/ATP ratios noninvasively. In addition to reduced PCr/ATP ratios observed in patients suffering from DCM, significantly-increased PDE/ATP ratios were found in patients with severe DCM.


Spectroscopy Dilated cardiomyopathy Chemical shift imaging High-energy phosphates 



The authors thank Ines Krumbein and Urte Jäger for excellent technical assistance.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • A. Hansch
    • 1
  • R. Rzanny
    • 1
  • J.-P. Heyne
    • 1
  • U. Leder
    • 2
  • J. R. Reichenbach
    • 1
  • W. A. Kaiser
    • 1
  1. 1.Institute of Diagnostic and Interventional RadiologyFriedrich Schiller University JenaJenaGermany
  2. 2.Department of Internal MedicineFriedrich Schiller University JenaJenaGermany

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