European Radiology

, Volume 14, Issue 10, pp 1829–1841 | Cite as

Initial experience with FSE STIR whole-body MR imaging for staging lymphoma in children

  • Christian J. Kellenberger
  • Stephen F. Miller
  • Mustafa Khan
  • David L. Gilday
  • Sheila Weitzman
  • Paul S. Babyn


Our objective was to compare fast spin-echo (FSE) short inversion time inversion recovery (STIR) whole-body MR imaging with standard procedures in staging children with lymphoma. Eight children (age range, 2–16 years) underwent multi-station FSE STIR whole-body MR at initial staging (n=5) or for restaging following completion of therapy (n=5). Whole-body MR and conventional staging procedures, including CT (n=10), gallium-67 scintigraphy (n=9), bone scintigraphy (n=3) and bone marrow biopsy (n=7) were retrospectively compared for detection of sites involved by lymphoma and for the assigned stage. FSE STIR whole-body MR detected more sites of possible lymphomatous involvement at initial staging (87/88) and at restaging (5/5) than did conventional imaging (74/88, 3/5). MR was more sensitive than conventional imaging in detecting bone marrow involvement at initial staging. Following treatment, however, residual and therapy-induced bone marrow signal abnormalities could not be differentiated from lymphomatous involvement. Detection of nodal and visceral involvement correlated well. Our results suggest that FSE STIR whole-body MR imaging is a sensitive technique for evaluating lymphomatous involvement of bone marrow as well as non-marrow sites. Larger prospective trials are needed to determine if FSE STIR whole-body MR can replace standard radiographic procedures for initial staging and contribute in the follow-up of lymphoma in children.


MRI Turbo STIR Whole-body MRI Paediatrics Neoplasm 


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Copyright information

©  2004

Authors and Affiliations

  • Christian J. Kellenberger
    • 1
  • Stephen F. Miller
    • 1
  • Mustafa Khan
    • 1
  • David L. Gilday
    • 1
  • Sheila Weitzman
    • 2
  • Paul S. Babyn
    • 1
  1. 1.Department of Diagnostic ImagingThe Hospital for Sick ChildrenTorontoCanada
  2. 2.Department of PaediatricsThe Hospital for Sick ChildrenTorontoCanada

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