European Radiology

, Volume 13, Issue 8, pp 1931–1936 | Cite as

Single breath-hold real-time cine MR imaging: improved temporal resolution using generalized autocalibrating partially parallel acquisition (GRAPPA) algorithm

  • Bernd J. WinterspergerEmail author
  • Konstantin Nikolaou
  • Olaf Dietrich
  • Johannes Rieber
  • Matthias Nittka
  • Maximilian F. Reiser
  • Stefan O. Schoenberg


The purpose of this study was to test parallel imaging techniques for improvement of temporal resolution in multislice single breath-hold real-time cine steady-state free precession (SSFP) in comparison with standard segmented single-slice SSFP techniques. Eighteen subjects were examined on a 1.5-T scanner using a multislice real-time cine SSFP technique using the GRAPPA algorithm. Global left ventricular parameters (EDV, ESV, SV, EF) were evaluated and results compared with a standard segmented single-slice SSFP technique. Results for EDV (r=0.93), ESV (r=0.99), SV (r=0.83), and EF (r=0.99) of real-time multislice SSFP imaging showed a high correlation with results of segmented SSFP acquisitions. Systematic differences between both techniques were statistically non-significant. Single breath-hold multislice techniques using GRAPPA allow for improvement of temporal resolution and for accurate assessment of global left ventricular functional parameters.


Heart Heart volume MR MR cine study MR volume measurement 


  1. 1.
    Barkhausen J, Goyen M, Ruhm SG, Eggebrecht H, Debatin JF, Ladd ME (2002) Assessment of ventricular function with single breath-hold real-time steady-state free precession cine MR imaging. Am J Roentgenol 178:731–735Google Scholar
  2. 2.
    Lee VS, Resnick D, Bundy JM, Simonetti OP, Lee P, Weinreb JC (2002) Cardiac function: MR evaluation in one breath-hold with real-time true fast imaging with steady-state precession. Radiology 222:835–842PubMedGoogle Scholar
  3. 3.
    Wintersperger BJ, Nikolaou K, Schoenberg SO, Nittka M, Huber AM, Reiser MF (2002) MRI cardiac function analysis in a single breath-hold: real-time TrueFISP with improved temporal resolution using integrated parallel acquisition techniques (iPAT). Radiology 225:P298Google Scholar
  4. 4.
    Griswold MA, Jakob PM, Heidemann RM, Nittka M, Jellus V, Wang J, Kiefer B, Haase A (2002) Generalized autocalibrating partially parallel acquisitions (GRAPPA). Magn Reson Med 47:1202–1210CrossRefPubMedGoogle Scholar
  5. 5.
    Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:307–310PubMedGoogle Scholar
  6. 6.
    Atkinson DJ, Edelman RR (1991) Cineangiography of the heart in a single breath-hold with a segmented turboFLASH sequence. Radiology 178:357–360PubMedGoogle Scholar
  7. 7.
    Sakuma H, Fujita N, Foo TK, Caputo GR, Nelson SJ, Hartiala J, Shimakawa A, Higgins CB (1993) Evaluation of left ventricular volume and mass with breath-hold cine MR imaging. Radiology 188:377–380PubMedGoogle Scholar
  8. 8.
    Lamb HJ, Doornbos J, van der Velde EA, Kruit MC, Reiber JH, de Roos A (1996) Echo planar MRI of the heart on a standard system: validation of measurements of left ventricular function and mass. J Comput Assist Tomogr 20:942–949CrossRefPubMedGoogle Scholar
  9. 9.
    Barkhausen J, Ruehm SG, Goyen M, Buck T, Laub G, Debatin JF (2001) MR evaluation of ventricular function: true fast imaging with steady-state precession versus fast low-angle shot cine MR imaging: feasibility study. Radiology 219:264–269PubMedGoogle Scholar
  10. 10.
    Moon JC, Lorenz CH, Francis JM, Smith GC, Pennell DJ (2002) Breath-hold FLASH and FISP cardiovascular MR imaging: left ventricular volume differences and reproducibility. Radiology 223:789–797PubMedGoogle Scholar
  11. 11.
    Weissler AM, Harris WS, Schoenfeld CD (1968) Systolic time intervals in heart failure in man. Circulation 37:149–159PubMedGoogle Scholar
  12. 12.
    Setser RM, Fischer SE, Lorenz CH (2000) Quantification of left ventricular function with magnetic resonance images acquired in real time. J Magn Reson Imaging 12:430–438CrossRefPubMedGoogle Scholar
  13. 13.
    Miller S, Simonetti OP, Carr J, Kramer U, Finn JP (2002) MR imaging of the heart with cine true fast imaging with steady-state precession: influence of spatial and temporal resolutions on left ventricular functional parameters. Radiology 223:263–269PubMedGoogle Scholar
  14. 14.
    Schalla S, Nagel E, Lehmkuhl H, Klein C, Bornstedt A, Schnackenburg B, Schneider U, Fleck E (2001) Comparison of magnetic resonance real-time imaging of left ventricular function with conventional magnetic resonance imaging and echocardiography. Am J Cardiol 87:95–99Google Scholar
  15. 15.
    Peters DC, Korosec FR, Grist TM, Block WF, Holden JE, Vigen KK, Mistretta CA (2000) Undersampled projection reconstruction applied to MR angiography. Magn Reson Med 43:91–101Google Scholar
  16. 16.
    Schaeffter T, Weiss S, Eggers H, Rasche V (2001) Projection reconstruction balanced fast field echo for interactive real-time cardiac imaging. Magn Reson Med 46:1238–1241CrossRefPubMedGoogle Scholar
  17. 17.
    Larson AC, Simonetti OP (2001) Real-time cardiac cine imaging with SPIDER: steady-state projection imaging with dynamic echo-train readout. Magn Reson Med 46:1059–1066CrossRefPubMedGoogle Scholar
  18. 18.
    Plein S, Smith WH, Ridgway JP, Kassner A, Beacock DJ, Bloomer TN, Sivananthan MU (2001) Qualitative and quantitative analysis of regional left ventricular wall dynamics using real-time magnetic resonance imaging: comparison with conventional breath-hold gradient echo acquisition in volunteers and patients. J Magn Reson Imaging 14:23–30CrossRefPubMedGoogle Scholar
  19. 19.
    Nikolaou K, Schoenberg SO, Nittka M, Attenberger U, Behr J, Reiser MF (2003) High resolution magnetic resonance angiography and fast perfusion imaging in the diagnosis of pulmonary arterial hypertension: benefit of parallel imaging techniques. Eur Radiol 13 (Suppl 1):S161Google Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Bernd J. Wintersperger
    • 1
    Email author
  • Konstantin Nikolaou
    • 1
  • Olaf Dietrich
    • 1
  • Johannes Rieber
    • 2
  • Matthias Nittka
    • 3
  • Maximilian F. Reiser
    • 1
  • Stefan O. Schoenberg
    • 1
  1. 1.Department of Clinical RadiologyUniversity of Munich, Klinikum GrosshadernMunichGermany
  2. 2.Department of CardiologyUniversity of Munich, Klinikum GrosshadernMunichGermany
  3. 3.Siemens Medical SystemsErlangenGermany

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