European Radiology

, Volume 13, Issue 10, pp 2346–2352 | Cite as

Radio-frequency tissue ablation of the liver: in vivo and ex vivo experiments with four different systems

  • Alban L. Denys
  • Thierry De Baere
  • Viseth Kuoch
  • Benoit Dupas
  • Patrick Chevallier
  • David C. Madoff
  • Pierre Schnyder
  • Francesco Doenz
Experimental

Abstract

The aim of this study was to test the efficacy of four different radio-frequency ablation (RFA) systems in normal hepatic parenchyma in large animals. The RFA was applied to pig livers in vivo and to calf livers ex vivo using the Radionics cluster needle, RITA starburst XL needle, Radiotherapeutics Le Veen 4.0 needle, and the Berchtold 14-G saline-perfused 15-mm active-tip needle based on constructor specifications. The volume of tissue coagulation from RF was calculated from measurements of the vertical diameter (Dv) and transverse diameter (Dt). Lesion shape was characterized using the ratio between Dt/Dv. Radiotherapeutics and RITA produced in vivo lesion volume of 42±10, 39±4 cm3 with a reproducible spherical shape (Dt/Dv of 1.01±0.16 and 0.97±0.1, respectively). Radionics produced in vivo RF lesions volume of 29±11 cm3 with an ovoid shape (Dt/Dv 0.88±0.09). The RF lesions with the Berchtold device could not be assessed in vivo as 5 of 8 animals died during treatment. Ex vivo RF lesions had similar volumes with each system; however, the Radiotherapeutics device produced more reproducible shaped lesions than the other systems. In our experimental study, we found no difference between expandable needle systems in vivo. Cooled needles produced slightly smaller and ovoid shape in vivo lesions.

Keywords

Experimental study Radio-frequency ablation Liver Electrode 

Notes

Acknowledgement We thank P. Frascarolo for his precious help in the statistical evaluation of our results.

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Alban L. Denys
    • 1
  • Thierry De Baere
    • 2
  • Viseth Kuoch
    • 2
  • Benoit Dupas
    • 3
  • Patrick Chevallier
    • 1
  • David C. Madoff
    • 4
  • Pierre Schnyder
    • 1
  • Francesco Doenz
    • 1
  1. 1.Department of Radiology and Interventional RadiologyCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
  2. 2.Department of Interventional RadiologyInstitut Gustave Roussy
  3. 3.Department of RadiologyCHU Hotel DieuNantes Cedex 1France
  4. 4.Department of Interventional RadiologyUniversity of Texas, M.D. Anderson Cancer CenterHoustonUSA

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