Plant Cell Reports

, Volume 30, Issue 2, pp 137–151

Tail-anchored membrane proteins: exploring the complex diversity of tail-anchored-protein targeting in plant cells

Review

DOI: 10.1007/s00299-010-0925-6

Cite this article as:
Abell, B.M. & Mullen, R.T. Plant Cell Rep (2011) 30: 137. doi:10.1007/s00299-010-0925-6

Abstract

Tail-anchored (TA) proteins are special class of integral membrane proteins that in recent years have received a considerable amount of attention due to their diverse cellular functions and unique targeting and insertion mechanisms. Defined by the presence of a single, hydrophobic membrane-spanning domain at or near their C terminus, TA proteins must be inserted into membranes post-translationally and are orientated such that their larger N-terminal domain (most often the functional domain) faces the cytosol, while their shorter C-terminal domain faces the interior of the organelle. The C-terminal domain of TA proteins also usually contains the information responsible for their selective targeting to the proper subcellular membrane, a process that, based primarily on studies with yeasts and mammals, appears to be highly complex due to the presence of multiple pathways. Within this context, we discuss here the biogenesis of plant TA proteins and the potential for hundreds of new TA proteins identified via bioinformatics screens to contribute to the already remarkable number of roles that this class of membrane proteins participates in throughout plant growth and development.

Keywords

Biogenesis Membrane Organelle Protein trafficking Tail-anchored 

Abbreviations

AKR2A

Ankryin repeat-containing protein 2A

APX

Ascorbate peroxidase

Cb5

Cytochrome b5

DRP

Dynamin-related protein

ER

Endoplasmic reticulum

Fis1

FISSION 1

Get

Guided entry of tail-anchored proteins

MDAR

Monodehydroascorbate reductase

OEP

Outer envelope protein

Pex

Peroxin

PMD1

Peroxisomal and mitochondrial division factor 1

PMP

Peroxisomal membrane protein

SAM

Sorting and assembly machinery

SNARE

Soluble NSF attachment protein receptors

SRP

Signal recognition particle

TA

Tail-anchored

TOC

Chloroplast outer envelope translocase

TOM

Mitochondrial outer membrane translocase

TMD

Transmembrane domain

TPR

Tetratricopeptide repeat

WIP

(Trp-Pro-Pro)-domain-interacting protein

WIT

(Trp-Pro-Pro)-domain interacting tail-anchored protein

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Biomedical Research CentreSheffield Hallam UniversitySheffieldUK
  2. 2.Department of Molecular and Cellular BiologyUniversity of GuelphGuelphCanada

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