Plant Cell Reports

, Volume 24, Issue 11, pp 629–641

Microalgae as bioreactors

  • Tara L. Walker
  • Saul Purton
  • Douglas K. Becker
  • Chris Collet
Review

DOI: 10.1007/s00299-005-0004-6

Cite this article as:
Walker, T.L., Purton, S., Becker, D.K. et al. Plant Cell Rep (2005) 24: 629. doi:10.1007/s00299-005-0004-6

Abstract

Microalgae already serve as a major natural source of valuable macromolecules including carotenoids, long-chain polyunsaturated fatty acids and phycocolloids. As photoautotrophs, their simple growth requirements make these primitive plants potentially attractive bioreactor systems for the production of high-value heterologous proteins. The difficulty of producing stable transformants has meant that the field of transgenic microalgae is still in its infancy. Nonetheless, several species can now be routinely transformed and algal biotechnology companies have begun to explore the possibilities of synthesizing recombinant therapeutic proteins in microalgae and the engineering of metabolic pathways to produce increased levels of desirable compounds. In this review, we compare the current commercially viable bioreactor systems, outline recent progress in microalgal biotechnology and transformation, and discuss the potential of microalgae as bioreactors for the production of heterologous proteins.

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Tara L. Walker
    • 1
  • Saul Purton
    • 2
  • Douglas K. Becker
    • 1
  • Chris Collet
    • 1
  1. 1.Cluster for Molecular Biotechnology, Science Research Centre and CRC for DiagnosticsQueensland University of TechnologyBrisbaneAustralia
  2. 2.Department of BiologyUniversity College LondonLondonUnited Kingdom

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