Rheumatology International

, Volume 21, Issue 2, pp 58–61 | Cite as

Association of T102C polymorphism of the 5-HT2A receptor gene with pyschiatric status in fibromyalgia syndrome

  • Savaş Gürsoy
  • Emin Erdal
  • Hasan Herken
  • Ercan Madenci
  • Belgin Alaşehirli
Original Article

Abstract.

Serotonin (5-HT) is a key neurotransmitter in the central nervous system. It is suggested that serotonergic dysfunction may be involved in the pathophysiology of fibromyalgia syndrome (FS). In this study, we aimed to investigate T102C polymorphism of the 5-HT2A receptor gene in FS. Fifty-eight patients with FS and 58 unrelated healthy volunteer controls were included in the study. In both groups, the C/C, C/T, and T/T genotypes of the 5-HT gene were represented in 31% (22.4% in controls), 50% (53.4%), and 19% (24.1%), respectively. The 5-HT2A receptor gene polymorphism results were not significantly different between patients and controls (chi squared test, P>0.05). There was a significant correlation between patients with the T/T genotype and the subgroup according to the SCL-90-R test, (analysis of variance, P<0.05). We also saw that patients with the T/T genotype had the lowest pain threshold. Conclusion. T102C polymorphism of the 5-HT2A receptor gene is not associated with the etiology of FS. Our results also indicate that the T/T genotype may be responsible for psychiatric symptoms of FS.

Fibromyalgia syndrome Polymorphism Psychiatric status Serotonin receptor gene 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Savaş Gürsoy
    • 1
  • Emin Erdal
    • 2
  • Hasan Herken
    • 1
  • Ercan Madenci
    • 1
  • Belgin Alaşehirli
    • 1
  1. 1.Department of PMR, Medical Hospital, 27200 Kolejtep Gaziantep, Turkey
  2. 2.Mersin University, Department of the Medical Biology, 33000 Mersin, Turkey

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