Rheumatology International

, Volume 20, Issue 5, pp 192–196 | Cite as

Increased level of YKL-40 in sera from patients with early rheumatoid arthritis: a new marker for disease activity

  • Ritva Peltomaa
  • Leena Paimela
  • Sheryl Harvey
  • Tapani Helve
  • Marjatta Leirisalo-Repo
Original Article

Abstract.

YKL-40 is a newly discovered major secretory protein of human chondrocytes and synoviocytes. We measured serum levels of YKL-40 in 52 patients with early onset rheumatoid arthritis (RA) by enzyme-linked immunosorbent assay (ELISA) during a 2-year prospective follow-up, correlating values with laboratory and clinical variables and radiographic progression. Levels at baseline before antirheumatic therapy were significantly higher in patients than in healthy controls. The levels of YKL-40 correlated with laboratory and clinical markers of disease activity both at baseline and during follow-up. Baseline YKL-40 values correlated with baseline Larsen scores but did not predict radiographic progression. Baseline and mean YKL-40 values did not differ between fast and slow radiological progressions. Mean YKL-40 levels correlated with the number of swollen joints but were not predictors of radiographic progression. These results suggest that in early RA, serum YKL-40 is an inflammatory marker correlating with disease activity. However, its levels do not predict clinical course or radiographic progression.

YKL-40 Early rheumatoid arthritis 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Ritva Peltomaa
    • 1
  • Leena Paimela
    • 2
  • Sheryl Harvey
    • 3
  • Tapani Helve
    • 4
  • Marjatta Leirisalo-Repo
    • 5
  1. 1.Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Kasarmikatu 11–13, 00130 Helsinki, Finland
  2. 2.Invalid Foundation, Tenholantie 10, 00280 Helsinki, Finland
  3. 3.Novadex Inc., 11526 Sorrento Valley Road Suite B, San Diego, CA 92121, USA
  4. 4.Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Kasarmikatu 11–13, 00130 Helsinki, Finland
  5. 5.Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Kasarmikatu 11–13, 00130 Helsinki, Finland

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