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Rheumatology International

, Volume 18, Issue 4, pp 147–151 | Cite as

Pulmonary hypertension in systemic lupus erythematosus

  • J.-Y. Shen
  • Shun-Le Chen
  • Yi-Xian Wu
  • R.-Q. Tao
  • Yue-Ying Gu
  • Chun-De Bao
  • Qin Wang
ORIGINAL ARTICLE

Abstract

A prospective echocardiographic and clinical study was performed on 84 Chinese patients with systemic lupus erythematosus (SLE) and 99 controls to investigate the prevalence and the mechanism of pulmonary hypertension (PH) in SLE. Comparison between Doppler estimation and catheterization measurement was made in 12 cases to validate the predictive method. Compared to normal subjects, lupus patients had significantly increased sys-tolic pulmonary artery pressure (SPAP) (29.59±12.52 vs 19.64±5.82, P<0.001), mean pulmonary artery pressure (MPAP) (15.11±7.36 vs 10.21±4.72, P<0.001) and total pulmonary resistance (TPR) (315.85±190.65 vs 220.37± 55.92, P<0.001). Nine of the 84 patients presented PH, defined as SPAP >30 mmHg and MPAP >20 mmHg. Pulmonary hypertensive patients had higher serum endothelin (ET) than non-pulmonary hypertensive patients, were more commonly in active stages, and presented Raynaud's phenomenon and rheumatoid factors. ET level was correlated with echocardiographic pulmonary pressure. Pulmonary hypertension commonly occurs in Chinese patients with SLE (11%), and it correlates with the lupus activity and the elevation of serum endothelin.

Key words Systemic lupus erythematosus Pulmonary hypertension Echocardiography Cardiac catheterization Endothelin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • J.-Y. Shen
    • 1
  • Shun-Le Chen
    • 2
  • Yi-Xian Wu
    • 1
  • R.-Q. Tao
    • 1
  • Yue-Ying Gu
    • 2
  • Chun-De Bao
    • 2
  • Qin Wang
    • 3
  1. 1.Department of Cardiology, Ren Ji Hospital, Shanghai Second Medical University, Shanghai 200001, People's Republic of ChinaCN
  2. 2.Department of Immunology, Ren Ji Hospital, Shanghai Second Medical University, Shanghai, People's Republic of ChinaCN
  3. 3.RIA Center, Ren Ji Hospital, Shanghai Second Medical University, Shanghai, People's Republic of ChinaCN

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