Positive conversion of interferon-γ release assay in patients with rheumatic diseases treated with biologics
KeywordsInterferon-γ release assay Biologics Tuberculosis Rheumatoid arthritis Ankylosing spondylitis
This study was supported by a grant of the Korean Health Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI14C1774). We thank Hye Sun Lee, Ph.D. and Sinae Kim, M.S., Biostatistics Collaboration Unit, Yonsei University College of Medicine, for statistical consultation. We also thank Editage (https://www.editage.co.kr) for English editing.
HWK contributed to data collection and analysis, and manuscript writing. OCK contributed to data collection and analysis, and manuscript writing. HWK and OCK contributed equally as co-first authors in the study. SHH contributed to data collection and analysis, and critically reviewed the manuscript. M-CP contributed to the conception and design of the study, data collection and analysis, manuscript writing, and final approval of the manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that there are no conflicts of interest in relation to this article.
All procedures were performed in accordance with the ethical standards of the Institutional Review Board of Gangnam Severance Hospital (IRB No: 3-2016-0240) and with the 1964 Helsinki declaration. The approval date of IRB was October 17, 2016.
Related congress abstract publication
Preliminary data of this study was presented in the poster presentation session of EULAR Congress 2017 that was held in Madrid, Spain; Min-Chan Park, Hye Won Kim, Sang Hoon Han (2017) Positive conversion of tuberculosis screening results and incidence of active tuberculosis infection in patients receiving biologic treatment. Ann Rheum Dis 76 Suppl 2:762. https://doi.org/10.1136/annrheumdis-2017-eular.1286; presentation number, FRI0717; and presentation date, June 16, 2017.
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