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Mediterranean diet and Psoriatic Arthritis activity: a multicenter cross-sectional study

  • Francesco CasoEmail author
  • Luca Navarini
  • Francesco Carubbi
  • Andrea Picchianti-Diamanti
  • Maria Sole Chimenti
  • Marco Tasso
  • Damiano Currado
  • Piero Ruscitti
  • Massimo Ciccozzi
  • Antonio Annarumma
  • Bruno Laganà
  • Roberto Perricone
  • Antonella Afeltra
  • Roberto Giacomelli
  • Raffaele Scarpa
  • Luisa Costa
Observational Research
  • 2 Downloads

Abstract

Diet is a modifiable factor implicated in chronic systemic inflammation, and the mediterranean dietary pattern is considered to be a healthy model in terms of morbidity and mortality. The main aim of this study was to evaluate the adherence to the mediterranean diet in patients with Psoriatic Arthritis (PsA) and its impact on disease activity. A cross-sectional observational study was conducted in a cohort of 211 consecutive PsA patients. We evaluated PsA activity by disease activity index for PSoriatic Arthritis (DAPSA) and composite psoriatic disease activity index (CPDAI). The NCEP-ACT III criteria were used to identify subjects with MetS, and in each subject, we evaluated body mass index (BMI). A validated 14-item questionnaire for the assessment of adherence to the mediterranean diet (PREDIMED) was recorded for all the enrolled subjects. Patients showed a median age of 55 (48–62) and disease duration was 76 (36–120) months. 27.01% of patients were classified as having MetS. The median of the mediterranean diet score (MDS) was 7 (6–9). A moderate adherence to mediterranean diet was found in 66.35% of the entire cohort; 15.64% and 18.01% of the patients showed low- and high adherence to the dietary pattern, respectively. We found a negative association between DAPSA and adherence to mediterranean diet (B = − 3.291; 95% CI − 5.884 to − 0.698). DAPSA was positively associated with BMI (B = 0.332; 95% CI 0.047–0.618) and HAQ ( B = 2.176; 95% CI 0.984–3.368). Results from our study evidenced that in PsA patients, higher levels of disease activity as measured by DAPSA correlated with low adherence to mediterranean diet, suggesting potential benefit of antinflammatory properties of this dietary pattern.

Keywords

Body mass index C-reactive protein DAPSA Mediterranean diet Psoriatic Arthritis 

Notes

Author contribution

All authors made substantial contributions to the conception or design of the work, the acquisition, and interpretation of data. All authors contributed to the critical review and revision of the manuscript and approved the final version. All the authors agreed to be accountable for all aspects of the work. FC study design, data acquisition, statistical analysis, interpretation of data, writing of the first draft of the paper, review, and acceptance; LN study design, data acquisition, statistical analysis, interpretation of data, writing of the first draft of the paper, review, and acceptance; FC study design, data acquisition, interpretation of data, review, and acceptance; APD study design, data acquisition, interpretation of data, review, and acceptance; MSC study design, data acquisition, interpretation of data, review, and acceptance; MT study design, data acquisition, interpretation of data, review, and acceptance; DC study design, data acquisition, interpretation of data, review, and acceptance; PR study design, data acquisition, interpretation of data, review, and acceptance; MC study design, statistical analysis interpretation of data, review, and acceptance; AA study design, data acquisition, interpretation of data, review, and acceptance; BL study design, data acquisition, interpretation of data, review, and acceptance; RP study design, data acquisition, interpretation of data, review, and acceptance; AA study design, data acquisition, interpretation of data, review, and acceptance; RG study design, data acquisition, interpretation of data, review, and acceptance; RS study design, data acquisition, interpretation of data, review, and acceptance; LC study design, data acquisition, interpretation of data, writing of the first draft of the paper, review, and acceptance.

Funding

No specific funding was received for this work.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest in this work. Francesco Caso: conflict of interest and relationships with pharma agencies—none; Luca Navarini: conflict of interest and relationships with pharma agencies—none; Francesco Carubbi: conflict of interest and relationships with pharma agencies—none; Andrea Picchianti-Diamanti: conflict of interest and relationships with pharma agencies—none; Maria Sole Chimenti: conflict of interest and relationships with pharma agencies—none; Marco Tasso: conflict of interest and relationships with pharma agencies—none; Damiano Currado: conflict of interest and relationships with pharma agencies—none; Piero Ruscitti: conflict of interest and relationships with pharma agencies—PR received speaker honoraria and/or grants from BMS, MSD, Ely Lilly, SOBI and Pfizer outside this work; Massimo Ciccozzi: conflict of interest and relationships with pharma agencies—none; Antonio Annarumma: conflict of interest and relationships with pharma agencies—none; Bruno Laganà: conflict of interest and relationships with pharma agencies—none; Roberto Perricone: conflict of interest and relationships with pharma agencies—none; Antonella Afeltra: conflict of interest and relationships with pharma agencies—none; Roberto Giacomelli: conflict of interest and relationships with pharma agencies—RG received speaker honoraria and/or grants from Abbvie, Roche, Actelion, BMS, MSD, Ely Lilly, SOBI and Pfizer outside this work; Raffaele Scarpa: conflict of interest and relationships with pharma agencies—RS received speaker honoraria and/or grants from Abbvie, Celgene, MSD, Ely Lilly, Novartis, and Pfizer; Luisa Costa: conflict of interest and relationships with pharma agencies—none.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Rheumatology Unit, Department of Clinical Medicine and Surgery, School of MedicineUniversity Federico II of NaplesNaplesItaly
  2. 2.Unit of Allergology, Clinical Immunology and RheumatologyUniversità Campus Bio-Medico di RomaRomeItaly
  3. 3.Rheumatology Unit, Department of Biotechnological and Applied Clinical SciencesUniversity of L’AquilaL’AquilaItaly
  4. 4.Department of Clinical and Molecular Medicine, Sant’Andrea University HospitalSapienza University of RomeRomeItaly
  5. 5.Rheumatology, Allergology and Clinical ImmunologyUniversity of Rome Tor VergataRomeItaly
  6. 6.Unit of Clinical Laboratory ScienceUniversità Campus Bio-Medico di RomaRomeItaly

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