Familial Mediterranean fever and atherosclerosis in childhood and adolescence

  • Olga VampertziEmail author
  • Kyriaki Papadopoulou-Legbelou
  • Areti Triantafyllou
  • Stella Douma
  • Efimia Papadopoulou-Alataki


Familial Mediterranean fever is a chronic inflammatory disease characterized by periodic and self-limited episodes of fever and aseptic polyserositis. Although colchicine treatment has altered the course of the disease, it is believed that subclinical inflammation is still present, leading to endothelial dysfunction and atherosclerosis in the course of time. In this review, following the published recommendations, we queried online databases such as MEDLINE Pubmed, Scopus, and Web of science for peer-reviewed studies and reviews written in English language, using the following keywords: familial Mediterranean fever, children, endothelial dysfunction, atherosclerosis, cardiovascular disease. The objective of this review is to highlight the correlation between familial Mediterranean fever and atherosclerosis, and moreover to describe new serum inflammatory markers and non-invasive methods of endothelial dysfunction, to detect the atherosclerosis process early starting from childhood.


Familial Mediterranean fever Children Endothelial dysfunction Atherosclerosis Cardiovascular disease 



Amyloid A


Autoinflammatory disease damage index


Asymmetric dimethylarginine


Augmentation index


C-reactive protein


Cardiovascular disease


Ejection fraction


Erythrocyte sedimentation rate


Flow-mediated dilation


Familial Mediterranean fever


High-density lipoprotein


Interleukin 1-β


Intima–media thickness


Mediterranean fever


Mean platelet volume


NOD-like receptor


Neutrophil–leukocyte ratio


NOD-like receptor family, pyrindomain


Plasminogen-1 activator inhibitor


Platelet–leukocyte ratio


Pulse wave analysis


Pulse wave velocity


Red cell distribution width


Serum amyloid A


Tissue Doppler Imaging


Triglyceride levels


Compliance with ethical standards

Conflict of interest

The author declares that they have no competing interests.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.4th Department of Pediatrics, “Papageorgiou” HospitalAristotle University of ThessalonikiThessalonikiGreece
  2. 2.3rd Department of Internal Medicine, “Papageorgiou” HospitalAristotle University of ThessalonikiThessalonikiGreece

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