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Familial Mediterranean fever and atherosclerosis in childhood and adolescence

  • Olga VampertziEmail author
  • Kyriaki Papadopoulou-Legbelou
  • Areti Triantafyllou
  • Stella Douma
  • Efimia Papadopoulou-Alataki
Review
  • 29 Downloads

Abstract

Familial Mediterranean fever is a chronic inflammatory disease characterized by periodic and self-limited episodes of fever and aseptic polyserositis. Although colchicine treatment has altered the course of the disease, it is believed that subclinical inflammation is still present, leading to endothelial dysfunction and atherosclerosis in the course of time. In this review, following the published recommendations, we queried online databases such as MEDLINE Pubmed, Scopus, and Web of science for peer-reviewed studies and reviews written in English language, using the following keywords: familial Mediterranean fever, children, endothelial dysfunction, atherosclerosis, cardiovascular disease. The objective of this review is to highlight the correlation between familial Mediterranean fever and atherosclerosis, and moreover to describe new serum inflammatory markers and non-invasive methods of endothelial dysfunction, to detect the atherosclerosis process early starting from childhood.

Keywords

Familial Mediterranean fever Children Endothelial dysfunction Atherosclerosis Cardiovascular disease 

Abbreviations

AA

Amyloid A

ADDI

Autoinflammatory disease damage index

ADMA

Asymmetric dimethylarginine

AI

Augmentation index

CRP

C-reactive protein

CVD

Cardiovascular disease

EF

Ejection fraction

ESR

Erythrocyte sedimentation rate

FMD

Flow-mediated dilation

FMF

Familial Mediterranean fever

HDL-C

High-density lipoprotein

IL-1β

Interleukin 1-β

IMT

Intima–media thickness

MEFV

Mediterranean fever

MPV

Mean platelet volume

NLR

NOD-like receptor

NLR

Neutrophil–leukocyte ratio

NLRP3

NOD-like receptor family, pyrindomain

PAI-1

Plasminogen-1 activator inhibitor

PLR

Platelet–leukocyte ratio

PWA

Pulse wave analysis

PWV

Pulse wave velocity

RDW

Red cell distribution width

SAA

Serum amyloid A

TDI

Tissue Doppler Imaging

TG

Triglyceride levels

Notes

Compliance with ethical standards

Conflict of interest

The author declares that they have no competing interests.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.4th Department of Pediatrics, “Papageorgiou” HospitalAristotle University of ThessalonikiThessalonikiGreece
  2. 2.3rd Department of Internal Medicine, “Papageorgiou” HospitalAristotle University of ThessalonikiThessalonikiGreece

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