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Rheumatology International

, Volume 40, Issue 2, pp 313–321 | Cite as

Profile of new referrals to a single pediatric rheumatology center in Turkey

  • Şerife Gül Karadağ
  • Hafize Emine Sönmez
  • Ayşe Tanatar
  • Figen Çakmak
  • Mustafa Çakan
  • Nuray Aktay AyazEmail author
Observational Research
  • 40 Downloads

Abstract

To describe the demographic characteristics and clinical features of patients referred to a pediatric rheumatology outpatient clinic in Turkey and to compare the final diagnoses with the previous literature data. All new patients referred to pediatric rheumatology outpatient clinic of Kanuni Sultan Süleyman Research and Training Hospital between March 2018 and March 2019 were enrolled to the study. Demographic data, referral patterns, disease related features, physical examination findings and final diagnoses of new referrals were collected prospectively. A total of 2982 new referrals were evaluated in 1-year period. Among them 1561 (52%) had a diagnosis of a rheumatic disease. The frequencies of most common rheumatic diseases were; periodic fever syndromes (47.3%), juvenile idiopathic arthritis (18%) and vasculitis (14.4%), respectively. Non-rheumatic conditions were diagnosed in 1243 patients, among them orthopedic/mechanic problems (27.4%) were the most frequent ones followed by vitamin D deficiency (17.5%) and dermatological problems (9.8%). Patients with non-rheumatic conditions comprised a large part of the pediatric rheumatology outpatient clinic. National registries are required to establish the frequencies of pediatric rheumatic diseases in Turkey.

Keywords

Juvenile idiopathic arthritis Pediatric rheumatology Periodic fever syndromes Rheumatic diseases 

Notes

Author contributions

ŞGK conceptualized and designed the study, drafted the initial manuscript, and had full access to all the data in the study; HES designed the study, conducted the data analyses, drafted the initial manuscript, and had full access to all the data in the study; AT, FÇ and MÇ drafted the initial manuscript; NAA conceptualized and designed the study, drafted the final manuscript, and had full access to all the data in the study and all authors reviewed and revised the manuscript and approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Funding

None.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interest.

Informed consent

All participants and parents provided written informed consent.

References

  1. 1.
    Symmons DP, Jones M, Osborne J, Sills J, Southwood TR, Woo P (1996) Pediatric rheumatology in the United Kingdom: data from the British Pediatric Rheumatology Group National Diagnostic Register. J Rheumatol 23:1975–1980PubMedGoogle Scholar
  2. 2.
    Bowyer S, Roettcher P (1996) Pediatric rheumatology clinic populations in the United States: results of a 3 year survey. Pediatric Rheumatology Database Research Group. J Rheumatol 23:1968–1974PubMedGoogle Scholar
  3. 3.
    Denardo BA, Tucker LB, Miller LC, Szer IS, Schaller JG (1994) Demography of a regional pediatric rheumatology patient population. Affiliated Children’s Arthritis Centers of New England. J Rheumatol 21:1553–1561PubMedGoogle Scholar
  4. 4.
    Malleson PN, Fung MY, Rosenberg AM (1996) The incidence of pediatric rheumatic diseases: results from the Canadian Pediatric Rheumatology Association Disease Registry. J Rheumatol 23:1981–1987PubMedGoogle Scholar
  5. 5.
    Rosenberg AM (1990) Analysis of a pediatric rheumatology clinic population. J Rheumatol 17:827–830PubMedGoogle Scholar
  6. 6.
    Rosenberg AM (2005) Longitudinal analysis of a pediatric rheumatology clinic population. J Rheumatol 32:1992–2001PubMedGoogle Scholar
  7. 7.
    Hashkes PJ (2003) Profile of a pediatric rheumatology practice in Israel. Clin Exp Rheumatol 21:123–128PubMedGoogle Scholar
  8. 8.
    Arkachaisri T, Tang SP, Daengsuwan T, Phongsamart G, Vilaiyuk S, Charuvanij S et al (2017) Paediatric rheumatology clinic population in Southeast Asia: are we different? Rheumatology (Oxford) 56:390–398.  https://doi.org/10.1093/rheumatology/kew446 CrossRefGoogle Scholar
  9. 9.
    Demir S, Sag E, Dedeoglu F, Ozen S (2018) Vasculitis in systemic autoinflammatory diseases. Front Pediatr 6:377CrossRefGoogle Scholar
  10. 10.
    Harry O, Yasin S, Brunner H (2018) Childhood-onset systemic lupus erythematosus: a review and update. J Pediatr 196:22–30CrossRefGoogle Scholar
  11. 11.
    Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J et al (2004) International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31:390–392PubMedGoogle Scholar
  12. 12.
    Gattorno M, Hofer M, Federici S, Vanoni F, Bovis F, Aksentijevich I et al (2019) Classification criteria for autoinflammatory recurrent fevers. Ann Rheum Dis 78:1025–1032CrossRefGoogle Scholar
  13. 13.
    Federici S, Sormani MP, Ozen S, Lachmann HJ, Amaryan G, Woo P et al (2015) Evidence-based provisional clinical classification criteria for autoinflammatory periodic fevers. Ann Rheum Dis 74:799–805CrossRefGoogle Scholar
  14. 14.
    Ruperto N, Ozen S, Pistorio A, Dolezalova P, Brogan P, Cabral DA et al (2010) EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation. Ann Rheum Dis 69:790–797CrossRefGoogle Scholar
  15. 15.
    Kone-Paut I, Shahram F, Darce-Bello M, Cantarini L, Cimaz R, Gattorno M et al (2016) Consensus classification criteria for paediatric Behcet’s disease from a prospective observational cohort: PEDBD. Ann Rheum Dis 75:958–964CrossRefGoogle Scholar
  16. 16.
    Petri M, Orbai AM, Alarcon GS, Gordon C, Merrill JT, Fortin PR et al (2012) Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 64:2677–2686CrossRefGoogle Scholar
  17. 17.
    Bohan A, Peter JB (1975) Polymyositis and dermatomyositis (first of two parts). N Engl J Med 292:344–347CrossRefGoogle Scholar
  18. 18.
    Bohan A, Peter JB (1975) Polymyositis and dermatomyositis (second of two parts). N Engl J Med 292:403–407CrossRefGoogle Scholar
  19. 19.
    Zulian F, Woo P, Athreya BH, Laxer RM, Medsger TA Jr, Lehman TJ et al (2007) The Pediatric Rheumatology European Society/American College of Rheumatology/European League against Rheumatism provisional classification criteria for juvenile systemic sclerosis. Arthritis Rheum 57:203–212CrossRefGoogle Scholar
  20. 20.
    Laxer RM, Zulian F (2006) Localized scleroderma. Curr Opin Rheumatol 18:606–613CrossRefGoogle Scholar
  21. 21.
    Harden RN, Bruehl S, Perez RS, Birklein F, Marinus J, Maihofner C et al (2010) Validation of proposed diagnostic criteria (the “Budapest Criteria”) for Complex Regional Pain Syndrome. Pain 150:268–274CrossRefGoogle Scholar
  22. 22.
    Maverakis E, Patel F, Kronenberg DG, Chung L, Fiorentino D, Allanore Y et al (2014) International consensus criteria for the diagnosis of Raynaud’s phenomenon. J Autoimmun 48–49:60–65CrossRefGoogle Scholar
  23. 23.
    Gewitz MH, Baltimore RS, Tani LY, Sable CA, Shulman ST, Carapetis J et al (2015) Revision of the Jones Criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography: a scientific statement from the American Heart Association. Circulation 131:1806–1818CrossRefGoogle Scholar
  24. 24.
    Sherry DD (2001) Textbook of pediatric rheumatology. WB Saunders Co, Philadelphia, pp 362–380Google Scholar
  25. 25.
    Ozen S, Bakkaloglu A, Dusunsel R, Soylemezoglu O, Ozaltin F, Poyrazoglu H et al (2007) Childhood vasculitides in Turkey: a nationwide survey. Clin Rheumatol 26:196–200PubMedGoogle Scholar
  26. 26.
    Sonmez HE, Armagan B, Ayan G, Barut K, Batu ED, Erden A et al (2018) Polyarteritis nodosa: lessons from 25 years of experience. Clin Exp Rheumatol 117:52–56Google Scholar
  27. 27.
    Navon Elkan P, Pierce SB, Segel R, Walsh T, Barash J, Padeh S et al (2014) Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy. N Engl J Med 370:921–931CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Rheumatology, Department of Pediatrics, Kanuni Sultan Süleyman Research and Training HospitalUniversity of Health ScienceKucukcekmeceTurkey

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