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Rheumatology International

, Volume 39, Issue 12, pp 2053–2060 | Cite as

Study of familial aggregation of autoimmune rheumatic diseases in Asian Indian patients with systemic lupus erythematosus

  • Arvind Ganapati
  • Gautham Arunachal
  • Suvrat Arya
  • Devika Shanmugasundaram
  • Lakshmanan Jeyaseelan
  • Sathish Kumar
  • Sumita Danda
  • Debashish DandaEmail author
Observational Research

Abstract

Systemic lupus erythematosus (SLE) and other autoimmune rheumatic diseases (AIRD) tend to co-aggregate in families, making positive familial history a risk factor. We aimed to estimate familial aggregation of AIRD in SLE patients and to compare between ones having a positive and negative family history of autoimmunity in our cohort. We included families of 157 consecutive SLE patients in a hospital-based, cross-sectional design for a three-generation pedigree study. Clinical and laboratory parameters of these patients were recorded. AIRD was seen in families of 39 SLE patients amounting to a familial prevalence of 24.8% [95% confidence interval (CI) 18.1, 31.6] with a relative risk (λ) of 4.3 for first-degree relatives (FDRs) and 1.1 for second-degree relatives (SDRs). SLE was the commonest AIRD seen in families of 19 patients with a familial prevalence of 12.1% (95% CI 7.0, 17.2) and λ of 78.2 for FDRs and 18.1 for SDRs. AIRD as a whole and SLE alone were seen more commonly with parental consanguinity (p < 0.05). Familial aggregation in SLE patients also showed a relatively higher percentage of affected males and lesser presentation with constitutional features (p < 0.05) than sporadic SLE patients. Rheumatoid arthritis (RA) was the second most common AIRD seen in 16/39 (41%) families with a RR of 3.1 in FDRs of SLE patients. In conclusion, Asian Indian SLE patients seem to have a high familial aggregation of AIRD, which is more pronounced in the background of parental consanguinity. SLE is the commonest AIRD seen amongst FDRs and SDRs of SLE patients, followed by RA, with FDRs being at highest risk.

Keywords

SLE Lupus Autoimmune rheumatic disease Familial lupus Familial autoimmunity 

Notes

Acknowledgements

The authors would like to thank the institutional review board of Christian Medical College, Vellore for approving this study (IRB 9459) dated 5/6/2015

Funding

Internal Fluid Grant of study (IRB 9459) dated 5/6/2015 of Christian Medical College, Vellore.

Compliance with ethical standards

Conflict of interest

The author(s) of the manuscript declare no conflict of interest.

Supplementary material

296_2019_4355_MOESM1_ESM.docx (16 kb)
Supplementary material 1 (DOCX 15 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Arvind Ganapati
    • 1
  • Gautham Arunachal
    • 2
  • Suvrat Arya
    • 1
  • Devika Shanmugasundaram
    • 3
  • Lakshmanan Jeyaseelan
    • 3
  • Sathish Kumar
    • 4
  • Sumita Danda
    • 2
  • Debashish Danda
    • 1
    Email author
  1. 1.Department of Clinical Immunology and RheumatologyChristian Medical College HospitalVelloreIndia
  2. 2.Department of Medical GeneticsChristian Medical College HospitalVelloreIndia
  3. 3.Department of BiostatisticsChristian Medical College HospitalVelloreIndia
  4. 4.Department of Child Health IIChristian Medical College HospitalVelloreIndia

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