Is Henoch–Schönlein purpura a susceptibility factor for functional gastrointestinal disorders in children?
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Henoch–Schönlein purpura (HSP), the most common childhood vasculitis is characterized by non-thrombocytopenic palpable purpura, arthritis/arthralgia, abdominal pain and renal involvement. Functional gastrointestinal disorders (FGIDs) are heterogeneous disease spectrum with unclear etiology and include the most common subtypes: functional dyspepsia, irritable bowel syndrome (IBS), functional abdominal pain and functional constipation. Formerly, FGIDs were known as non-organic disorders; however, recent advances revealed that low-grade inflammation may also play a role. We aimed to clarify whether HSP predisposes to FGIDs in pediatric population. Seventy-four children with HSP, diagnosed at least 6 months before the study and 78 healthy controls were enrolled to the study. Patients with red flag signs for organic GI disorders were excluded. Rome IV criteria were utilized for FGIDs diagnosis. We compared the frequencies of FGIDs between HSP patients and healthy subjects. We also examined the parameters including age, abdominal pain, arthralgia, bloody stool, renal involvement and treatment with corticosteroids and laboratory results at HSP diagnosis such as erythrocyte sedimentation rate, C-reactive protein, hemoglobin, leukocytes and platelet counts among patients with and without FGIDs. Overall FGIDs and IBS frequency were 35.1% (n = 26) and 10.8% (n = 8) in HSP patients, 19.2% (n = 15) and 2.6% (n = 2) in healthy controls, respectively. Disease characteristics and laboratory parameters at disease onset were similar between HSP patients with and without FGIDs. Overall FGIDs rate, particularly IBS were statistically higher in HSP patients. We speculate that children with preceding HSP may be predisposed to FGIDs. Since the FGIDs pathogenesis is still remains unclear, further studies are needed to confirm this hypothesis and clarify the etiology. Physicians also should pay attention to FGIDs in HSP patients with ongoing abdominal pain and thus prevent this comorbidity with dietary and psychologic measures.
KeywordsHenoch–Schönlein purpura Child Functional gastrointestinal disorder Abdominal pain Constipation Irritable bowel syndrome
Dr. RMKE and Dr. MY conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript. Dr. SB, Dr. GT, Dr. SY and Dr. DD collected data, carried out the initial analyses, and reviewed and revised the manuscript. Dr. DUA, Dr. OOM and Dr. HC designed the data collection instruments, and coordinated and supervised data collection, and critically reviewed the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
No funding was received.
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Conflict of interest
Authors Rabia Miray Kisla Ekinci, Sibel Balci, Okkes Ozgur Mart, Gokhan Tumgor, Sibel Yavuz, Halil Celik, Dilek Dogruel, Derya Ufuk Altintas, Mustafa Yilmaz declare that they have no conflicts of interest.
- 1.Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CG, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, Pusey CD, Rasmussen N, Rees AJ, Scott DG, Specks U, Stone JH, Takahashi K, Watts RA (2013) 2012 revised international chapel hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65:1–11. https://doi.org/10.1002/art.37715 CrossRefGoogle Scholar
- 12.García-Carrasco M, Mendoza-Pinto C, Autrán-Limón MA, Herrera Robles E, Méndez Martínez S, Etchegaray Morales I, Montiel Jarquín Á, Gálvez Romero JL, Soto-Santillán P, Galindo-Herrera J, López-Colombo A (2018) Prevalence of functional gastrointestinal disorders in adults with systemic lupus erythematosus. Lupus 27:788–793. https://doi.org/10.1177/0961203317747718 CrossRefGoogle Scholar
- 13.Ozen S, Pistorio A, Iusan SM, Bakkaloglu A, Herlin T, Brik R et al (2010) EULAR/PRINTO/PRES criteria for Henoch-Schönlein Purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: final classification criteria. Ann Rheum Dis 69:798–806CrossRefGoogle Scholar
- 23.Baysoy G, Güler-Baysoy N, Kesicioğlu A, Akın D, Dündar T, Pamukçu-Uyan A (2014) Prevalence of irritable bowel syndrome in adolescents in Turkey: effects of gender, lifestyle and psychological factors. Turk J Pediatr 56:604–611Google Scholar
- 26.De Angelis M, Montemurno E, Piccolo M, Vannini L, Lauriero G, Maranzano V, Gozzi G, Serrazanetti D, Dalfino G, Gobbetti M, Gesualdo L (2014) Microbiota and metabolome associated with immunoglobulin A nephropathy (IgAN). PLoS One 9:e99006. https://doi.org/10.1371/journal.pone.0099006 CrossRefGoogle Scholar