Rheumatology International

, Volume 38, Supplement 1, pp 339–346 | Cite as

The Russian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)

  • Irina Nikishina
  • Ekaterina Alexeeva
  • Svetlana Arsenyeva
  • Svetlana Salugina
  • Maria Kaleda
  • Alessandro Consolaro
  • Francesca Bovis
  • Nicolino Ruperto
  • For the Paediatric Rheumatology International Trials Organisation (PRINTO)
Open Access
Validation Studies
  • 36 Downloads

Abstract

The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Russian language. The reading comprehension of the questionnaire was tested in 10 JIA parents and patients. Each participating centre was asked to collect demographic, clinical data and the JAMAR in 100 consecutive JIA patients or all consecutive patients seen in a 6-month period and to administer the JAMAR to 100 healthy children and their parents. The statistical validation phase explored descriptive statistics and the psychometric issues of the JAMAR: the three Likert assumptions, floor/ceiling effects, internal consistency, Cronbach’s alpha, interscale correlations, test–retest reliability, and construct validity (convergent and discriminant validity). A total of 100 JIA patients (25% systemic, 19% oligoarticular, 38% RF-negative polyarthritis, 18% other categories) and 198 healthy children, were enrolled in two centres. The JAMAR components discriminated healthy subjects from JIA patients. All JAMAR components revealed good psychometric performances. In conclusion, the Russian version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and clinical research.

Keywords

Juvenile idiopathic arthritis Disease status Functional ability Health-related quality of life JAMAR 

Introduction

The aim of the present study was to cross-culturally adapt and validate the Russian parent, child/adult version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR) [1] in patients with juvenile idiopathic arthritis (JIA). The JAMAR assesses the most relevant parent/patient-reported outcomes in JIA, including overall well-being, functional status, health-related quality of life (HRQoL), pain, morning stiffness, disease activity/status/course, articular and extra-articular involvement, drug-related side effects/compliance and satisfaction with illness outcome.

This project was part of a larger multinational study conducted by the Paediatric Rheumatology International Trials Organisation (PRINTO) [2] aimed to evaluate the Epidemiology, Outcome and Treatment of Childhood Arthritis (EPOCA) in different geographic areas [3].

We report herein the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Russian language.

Materials and methods

The methodology employed has been described in detail in the introductory paper of the supplement [4]. In brief, it was a cross-sectional study of JIA children, classified according to the ILAR criteria [5, 6] and enrolled from January 2015 to January 2017. Children were recruited after Ethics Committee approval and consent from at least one parent.

The JAMAR

The JAMAR [1] includes the following 15 sections:

  1. 1.

    Assessment of physical function (PF) using 15 items in which the ability of the child to perform each task is scored as follows: 0 = without difficulty, 1 = with some difficulty, 2 = with much difficulty, and 3 = unable to do and not applicable if it was not possible to answer the question or the patient was unable to perform the task due to their young age or to reasons other than JIA. The total PF score ranges from 0 to 45 and has 3 components: PF-lower limbs (PF-LL); PF-hand and wrist (PF-HW) and PF-upper segment (PF-US) each scoring from 0 to 15 [7]. Higher scores indicating higher degree of disability [8, 9, 10].

     
  2. 2.

    Rating of the intensity of the patient’s pain on a 21-numbered circle visual analogue scale (VAS) [11].

     
  3. 3.

    Assessment of the presence of joint pain or swelling (present/absent for each joint).

     
  4. 4.

    Assessment of morning stiffness (present/absent).

     
  5. 5.

    Assessment of extra-articular symptoms (fever and rash) (present/absent).

     
  6. 6.

    Rating of the level of disease activity on a 21-circle VAS.

     
  7. 7.

    Rating of disease status at the time of the visit (categorical scale).

     
  8. 8.

    Rating of disease course from previous visit (categorical scale).

     
  9. 9.

    Checklist of the medications the patient is taking (list of choices).

     
  10. 10.

    Checklist of side effects of medications.

     
  11. 11.

    Report of difficulties with medication administration (list of items).

     
  12. 12.

    Report of school/university/work problems caused by the disease (list of items).

     
  13. 13.

    Assessment of HRQoL, through the Physical Health (PhH), and Psychosocial Health (PsH) subscales (five items each) and a total score. The four-point Likert response, referring to the prior month, are ‘never’ (score = 0), ‘sometimes’ (score = 1), ‘most of the time’ (score = 2) and ‘all the time’ (score = 3). A ‘not assessable’ column was included in the parent version of the questionnaire to designate questions that cannot be answered because of developmental immaturity. The total HRQoL score ranges from 0 to 30, with higher scores indicating worse HRQoL. A separate score for PhH and PsH (range 0–15) can be calculated [12, 13, 14].

     
  14. 14.

    Rating of the patient’s overall well-being on a 21-numbered circle VAS.

     
  15. 15.

    A question about satisfaction with the outcome of the illness (Yes/No) [15].

     

The JAMAR is available in three versions, one for parent proxy-report (child’s age 2–18), one for child self-report, with the suggested age range of 7–18 years, and one for adults.

Cross-cultural adaptation and validation

The process of cross-cultural adaptation was conducted according to the international guidelines with 2–3 forward and backward translations. In those countries for which the translation of JAMAR had been already cross-cultural adapted in a similar language (i.e. Spanish in South American countries), only the probe technique was performed. Reading comprehension and understanding of the translated questionnaires were tested in a probe sample of 10 JIA parents and 10 patients.

Each participating centre was asked to collect demographic, clinical data and the JAMAR in 100 consecutive JIA patients or all consecutive patients seen in a 6-month period and to administer the JAMAR to 100 healthy children and their parents.

The statistical validation phase explored the descriptive statistics and the psychometric issues [16]. In particular, we evaluated the following validity components: the first Likert assumption (mean and standard deviation [SD] equivalence); the second Likert assumption or equal item–scale correlations (Pearson r: all items within a scale should contribute equally to the total score); third Likert assumption (item internal consistency or linearity for which each item of a scale should be linearly related to the total score that is 90% of the items should have Pearson r ≥ 0.4); floor/ceiling effects (frequency of items at lower and higher extremes of the scales, respectively); internal consistency, measured by the Cronbach’s alpha, interscale correlation (the correlation between two scales should be lower than their reliability coefficients, as measured by Cronbach’s alpha); test–retest reliability or intra-class correlation coefficient (reproducibility of the JAMAR repeated after 1 or 2 weeks); and construct validity in its two components: the convergent or external validity which examines the correlation of the JAMAR sub-scales with the six JIA core set variables, with the addition of the parent assessment of disease activity and pain by the Spearman’s correlation coefficients (r) [17] and the discriminant validity, which assesses whether the JAMAR discriminates between the different JIA categories and healthy children [18]. Quantitative data were reported as medians with 1st and 3rd quartiles and categorical data as absolute frequencies and percentages.

The complete Russian parent and patient versions of the JAMAR are available upon request to PRINTO.

Results

Cross-cultural adaptation

The Russian JAMAR was fully cross-culturally adapted from the standard English version with three forward and two backward translations with concordance in 117/123 translation lines (95.1%) for the parent version and 104/120 lines (86.7%) for the child version.

All 123 lines of the parent version of the JAMAR were understood by at least 80% of the 10 parents tested (median = 100%; range: 100–100%). All the 120 lines of the patient version of the JAMAR were understood by at least 80% of the children (median = 100%; range: 100–100%). The parent and child versions of the Russian JAMAR were unmodified after the probe technique.

Demographic and clinical characteristics of the subjects

A total of 100 JIA patients and 198 healthy children (total of 298 subjects) were enrolled at two paediatric rheumatology centres.

In the 100 JIA subjects, the JIA categories were 25% with systemic arthritis, 19% with oligoarthritis, 38% with RF-negative polyarthritis, 3% with RF-positive polyarthritis and 15% with enthesitis-related arthritis. Notably, none of the enrolled JIA patients is affected with psoriatic arthritis and with undifferentiated arthritis. (Table 1).

Table 1

Descriptive statistics (medians, 1st–3rd quartiles or absolute frequencies and %) for the 100 JIA patients

 

Systemic

Oligoarthritis

RF − poly-arthritis

RF + poly-arthritis

Enthesitis-related arthritis

All JIA patients

Healthy

N = 25

N = 19

N = 38

N = 3

N = 15

N = 100

N = 198

Female

17 (68%)

13 (68.4%)

28 (73.7%)

3 (100%)

7 (46.7%)

68 (68%)

98 (49.5%)*

Age at visit

9.7 (5.5–13.8)

13.1 (10.9–15.2)

14.1 (10.3–16.2)

17.1 (16–17.9)

13.1 (9.5–16.2)

12.9 (9.6–16)*

10.4 (8.7–12.7)*

Age at onset

2.7 (2–5.8)

4 (3–6.2)

4.9 (2–7.2)

10 (9–14.7)

8.6 (3.9–10.7)

4.8 (2.2–7.4)*

 

Disease duration

4.5 (1.1–8.9)

8.1 (5.4–11.2)

9 (4.7–11.1)

7.9 (1.3–8.1)

4.7 (1.5–7.2)

7.4 (2.6–10.2)*

 

ESR

15 (7–22)

9 (9–15)

12.5 (8–19)

(–)

11 (3–14)

12 (8–18)

 

MD VAS (0–10 cm)

1.5 (0.5–4)

1.5 (1–3)

3.3 (1–4.5)

1 (0.5–1.5)

1.5 (0.5–3)

2 (0.5–3.8)

 

No. of swollen joints

0 (0–1)

0 (0–2)

1.5 (0–4)

0 (0–1)

1 (0–2)

0 (0–3)

 

No. of joints with pain

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–0)

 

No. of joints with LOM

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–0)

0 (0–0)

 

No. of active joints

0 (0–2)

0 (0–2)

1.5 (0–4)

0 (0–1)

1 (0–2)

1 (0–3)

 

Active systemic features

1 (4%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

1 (1%)

 

ANA status

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

0 (0%)

 

Uveitis

0 (0%)

1 (5.3%)

1 (2.6%)

0 (0%)

0 (0%)

2 (2%)

 

PF total score

0 (0–5)

0 (0–1)

1.5 (0–4)

0 (0–3)

1 (0–3)

0 (0–3.5)

0 (0–0)#

Pain VAS

1 (0–4)

1.5 (0.5–3.5)

2 (1–5)

1 (0–1.5)

1.5 (0.5–4)

1.5 (0.5–4)

0 (0–0)#

Disease activity VAS

1.5 (0.5–4)

1 (0.5–1.5)

2.8 (1–5)

1 (0–1)

1.5 (1–3.5)

1.5 (0.5–4)

 

Well-being VAS

1.5 (0.5–3.5)

2 (0.5–4)

2.8 (1–4)

0.5 (0–2)

1.5 (0.5–4)

2 (0.5–3.8)

 

HRQoL-PhH

2 (0–4)

0 (0–1)

1 (0–3)

0 (0–2)

1 (0–2)

1 (0–3)

0 (0–0)#

HRQoL-PsH

3 (0–5)

1 (0–3)

1.5 (0–3)

0 (0–4)

3 (1–3)

2 (0–3)

0 (0–1)#

HRQoL total score

5 (1–9)

3 (0–3)

3 (0–6)

2 (0–4)

3 (1–5)

3 (0–5)

0 (0–1)#

Pain/swell. in > 1 joint

7 (28%)

7 (36.8%)

22 (57.9%)

0 (0%)

9 (60%)

45 (45%)*

0 (0%)#

Morning stiffness > 15 min

2 (8%)

0 (0%)

7 (18.4%)

0 (0%)

1 (6.7%)

10 (10%)

0 (0%)#

Subjective remission

9 (36%)

3 (15.8%)

18 (47.4%)

0 (0%)

4 (26.7%)

34 (34%)

 

In treatment

23 (92%)

19 (100%)

38 (100%)

3 (100%)

13 (86.7%)

96 (96%)

 

Reporting side effects

5/23 (21.7%)

1 (5.3%)

5 (13.2%)

0 (0%)

1/13 (7.7%)

12/96 (12.5%)

 

Taking medication regularly

22/23 (95.7%)

19 (100%)

36 (94.7%)

2 (66.7%)

13/13 (100%)

92/96 (95.8%)

 

With problems attending school

0 (0%)

0 (0%)

3/31 (9.7%)

0 (0%)

0 (0%)

3/75 (4%)

0 (0%)*

Satisfied with disease outcome

23 (92%)

19 (100%)

33 (86.8%)

3 (100%)

14 (93.3%)

92 (92%)

 

Data related to the JAMAR refer to the 100 JIA patients and to the 197 healthy subjects for whom the questionnaire has been completed by the parents

JAMAR Juvenile Arthritis Multidimensional Assessment Report, ESR erythrocyte sedimentation rate, MD medical doctor, VAS visual analogue scale (score 0–10; 0 = no activity, 10 = maximum activity), LOM limitation of motion, ANA anti-nuclear antibodies, PF physical function (total score ranges from 0 to 45), HRQoL health-related quality of life (total score ranges from 0 to 30), PhH physical health (total score ranges from 0 to 15), PsH psychosocial health (total score ranges from 0 to 15)

p values refer to the comparison of the different JIA categories or to JIA versus healthy. *p < 0.05, **p < 0.001, #p < 0.0001

A total of 297/298 (99.7%) subjects had the parent version of the JAMAR completed by a parent (100 from parents of JIA patients and 197 from parents of healthy children). The JAMAR was completed by 286/297 (96.3%) mothers and 11/297 (3.7%) fathers. The child version of the JAMAR was completed by 289/298 (97%) children age 5.0 or older. Also patients younger than 7 years old, capable to assess their personal condition and able to read and write, were asked to fill in the patient version of the questionnaire.

Discriminant validity

The JAMAR results are presented in Table 1, including the scores [median (1st–3rd quartile)] obtained for the PF, the PhH, the PsH subscales and total score of the HRQoL scales. The JAMAR components discriminated well between healthy subjects and JIA patients.

In summary, the JAMAR revealed that JIA patients had a greater level of disability and pain, as well as a lower HRQoL than their healthy peers.

Psychometric issues

The main psychometric properties of both parent and child versions of the JAMAR are reported in Table 2. “Results” refer mainly to the parent’s version findings, unless otherwise specified.

Table 2

Main psychometric characteristics between the parent and child version of the JAMAR

 

Parent N = 100/297

Child N = 92/289

Missing values (1st–3rd quartiles)

No missing values

No missing values

Response pattern

PF and HRQoL positively skewed

PF and HRQoL positively skewed

Floor effect, median

 PF

86.0%

85.9%

 HRQoL-PhH

69.0%

60.9%

 HRQoL-PsH

62.0%

64.1%

 Pain VAS

17.0%

40.2%

 Disease activity VAS

15.0%

32.6%

 Well-being VAS

14.0%

27.2%

Ceiling effect, median

 PF

1.0%

1.1%

 HRQoL-PhH

2.0%

3.3%

 HRQoL-PsH

1.0%

3.3%

 Pain VAS

0.0%

1.1%

 Disease activity VAS

1.0%

0.0%

 Well-being VAS

0.0%

1.1%

Items with equivalent item–scale correlation

93% for PF, 100% for HRQoL

100% for PF, 90% for HRQoL

Items with item–scale correlation ≥ 0.4

80% for PF, 100% for HRQoL

100% for PF, 90% for HRQoL

Cronbach’s alpha

 PF-LL

0.86

0.81

 PF-HW

0.91

0.82

 PF-US

0.64

0.74

 HRQoL-PhH

0.91

0.79

 HRQoL-PsH

0.85

0.82

Items with item–scale correlation lower than the Cronbach’s alpha

100% for PF, 100% for HRQoL

100% for PF, 100% for HRQoL

Test–retest intraclass correlation

 PF total score

1.0

0.77

 HRQoL-PhH

0.94

0.74

 HRQoL-PsH

0.96

0.84

Spearman correlation with JIA core set variables, median

 PF

0.5

0.5

 HRQoL-PhH

0.2

0.5

 HRQoL-PsH

0.3

0.4

 Pain VAS

0.3

0.4

 Disease activity VAS

0.5

0.6

 Well-being VAS

0.4

0.4

JAMAR Juvenile Arthritis Multidimensional Assessment Report, JIA juvenile idiopathic arthritis, VAS visual analogue scale, PF physical function, HRQoL health-related quality of life, PhH physical health, PsH psychosocial health, PF-LL PF-lower limbs, PF-HW PF-hand and wrist, PF-US PF-upper segment

Descriptive statistics (first Likert assumption)

There were no missing results for all JAMAR items, since data were collected through a web-based system that did not allow to skip answers and input null values. The response pattern for both PF and HRQoL was positively skewed toward normal functional ability and normal HRQoL. All response choices were used for the different HRQoL items except for items 6 and 8, whereas a reduced number of response choices were used for all the PF items except for items from 1 to 5, item 7, item 9 and item 13.

The mean and SD of the items within a scale were roughly equivalent for the PF and for the HRQoL items. The median number of items marked as not applicable was 1% (0–2%) for the PF and 2.5% (2–4%) for the HRQoL.

Floor and ceiling effect

The median floor effect was 86% (81–92%) for the PF items, 69% (68–75%) for the HRQoL-PhH items, and 62% (57–66%) for the HRQoL-PsH items. The median ceiling effect was 1% (0–1%) for the PF items, 2% (2–3%) for the HRQoL-PhH items, and 1% (0–2%) for the HRQoL-PsH items. The median floor effect was 17% for the pain VAS, 15% for the disease activity VAS and 14% for the well-being VAS. The median ceiling effect was 0% for the pain VAS, 1% for the disease activity VAS and 0% for the well-being VAS.

Equal item–scale correlations (second Likert assumption)

Pearson item–scale correlations corrected for overlap were roughly equivalent for items within a scale for 93% of the PF items, with the exception of item 15, and for 100% of the HRQoL items.

Items internal consistency (third Likert assumption)

Pearson item–scale correlations were ≥ 0.4 for 80% of items of the PF (except for PF items 11, 12 and 15) and 100% of items of the HRQoL.

Cronbach’s alpha internal consistency

Cronbach’s alpha was 0.86 for PF-LL, 0.91 for PF-HW, and 0.64 for PF-US. Cronbach’s alpha was 0.91 for HRQoL-PhH and 0.85 for HRQoL-PsH.

Interscale correlation

The Pearson correlation of each item of the PF and the HRQoL with all items included in the remaining scales of the questionnaires was lower than the Cronbach’s alpha.

Test–retest reliability

Reliability was assessed in 5 JIA patients, by re-administering both versions (parent and child) of the JAMAR after a median of 9 days (range 8–10 days). The intraclass correlation coefficients (ICC) for the PF total score showed an almost perfect reproducibility (ICC = 1). The ICC for the HRQoL-PhH and the ICC for the HRQoL-PsH showed an almost perfect reproducibility (ICC = 0.94 and ICC = 0.96, respectively).

Convergent validity

The Spearman correlation of the PF total score with the JIA core set of outcome variables ranged from 0.2 to 0.6 (median = 0.5). The PF total score best correlation was observed with the number of active joints (r = 0.6, p < 0.001). For the HRQoL, the median correlation of the PhH with the JIA core set of outcome variables ranged from 0.2 to 0.3 (median = 0.2), whereas for the PsH ranged from 0.1 to 0.3 (median = 0.3). The HRQoL-PhH and the HRQoL-PsH showed the best correlation with the parent’s assessment of well-being (r = 0.5, p < 0.001 for both).

The median correlations between the pain VAS, the well-being VAS, and the disease activity VAS and the physician-centred and laboratory measures were 0.3 (0.1–0.5), 0.5 (0.2–0.6), 0.4 (0.3–0.5), respectively.

Discussion

In this study, the Russian version of the JAMAR was cross-culturally adapted from the original standard English version with three forward and two backward translations. According to the results of the validation analysis, the Russian parent and patient versions of the JAMAR possess satisfactory psychometric properties. The disease-specific components of the questionnaire discriminated well between patients with JIA and healthy controls.

Psychometric performances were good for all domains of the JAMAR with few exceptions: three PF items (“Stretch out arms”, “Put hands behind neck” and “Bite into a sandwich or an apple”) showed a lower items internal consistency. However, the overall internal consistency was good for all the domains, except for PF-US that is questionable.

In the external validity evaluation, the Spearman’s correlations of the PF and HRQoL scores with JIA core set parameters ranged from week to moderate.

The results obtained for the parent version of the JAMAR are very similar to those obtained for the child version, which suggests that children are equally reliable proxy reporters of their disease and health status as their parents. The JAMAR is aimed to evaluate the side effects of medications and school attendance, which are other dimensions of daily life that were not previously considered by other HRQoL tools. This may provide useful information for intervention and follow-up in health care. In conclusion, the Russian version of the JAMAR was found to have satisfactory psychometric properties and it is, thus, a reliable and valid tool for the multidimensional assessment of children with JIA.

Notes

Acknowledgements

We thank all families who participated in the project, the team that prepared and reviewed the forward and backward translations, and all members of PRINTO in Russian Federation. We thank the staff of the PRINTO International Coordinating Centre in Genoa (Italy) and in particular Marco Garrone for the overall coordination of the translation process, Silvia Scala and Elisa Patrone for data collection and quality assurance; Luca Villa, Giuseppe Silvestri and Mariangela Rinaldi for the database development and management and the remaining PRINTO team for data entry. We thank Olga Kostareva from the staff of the paediatric department of V.A. Nasonova Research Institute of Rheumatology in Moscow (Russian Federation) for the assistance in data collection. The Principal Investigator of the study was Prof. Angelo Ravelli, MD. The scientific coordinator and study methodologist was Nicolino Ruperto, MD, MPH. The project coordinators were Alessandro Consolaro, MD, PhD, Francesca Bovis, BsA. We thank also Prof. Alberto Martini, PRINTO Chairman. Funding was provided by the Istituto G. Gaslini, Genoa (Italy). Permission for use of JAMAR and its translations must be obtained in writing from PRINTO, Genoa, Italy. All JAMAR-related inquiries should be directed to at printo@gaslini.org. Permission for use of CHAQ and CHQ-derived material is granted through the scientific cooperation of the copyright holder ICORE of Woodside CA and HealthActCHQ Inc. of Boston, Massachusetts USA. All CHQ-related inquiries should be directed to licensing@healthactchq.com. All CHAQ-related inquiries should be directed to gsingh@stanford.edu.

Compliance with ethical standards

Conflict of interest

Dr. Ruperto has received grants from BMS, Hoffman-La Roche, Janssen, Novartis, Pfizer, Sobi, during the conduct of the study and personal fees and speaker honorarium from Abbvie, Ablynx, Amgen, AstraZeneca, Baxalta Biosimilars, Biogen Idec, Boehringer, Bristol Myers Squibb, Celgene, Eli-Lilly, EMD Serono, Gilead Sciences, Janssen, Medimmune, Novartis, Pfizer, Rpharm, Roche, Sanofi, Servier and Takeda. Dr. Consolaro, Dr. Bovis, Dr Nikishina, Dr Alexeeva, Dr Arsenyeva, Dr Salugina and Dr Kaleda have nothing to disclose.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study as per the requirement of the local ethical committee.

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Irina Nikishina
    • 1
  • Ekaterina Alexeeva
    • 2
  • Svetlana Arsenyeva
    • 1
  • Svetlana Salugina
    • 1
  • Maria Kaleda
    • 1
  • Alessandro Consolaro
    • 3
    • 4
  • Francesca Bovis
    • 3
  • Nicolino Ruperto
    • 3
  • For the Paediatric Rheumatology International Trials Organisation (PRINTO)
  1. 1.Pediatric DepartmentV.A. Nasonova Research Institute of RheumatologyMoscowRussian Federation
  2. 2.Rheumatology DepartmentState Institution Scientific Center of Children Health of Rams MoscowMoscowRussian Federation
  3. 3.Clinica Pediatrica e Reumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO)Istituto Giannina GasliniGenoaItaly
  4. 4.Dipartimento di PediatriaUniversità di GenovaGenoaItaly

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