Rheumatology International

, Volume 36, Issue 10, pp 1431–1437 | Cite as

Pregnancy outcomes in women with childhood-onset and adult-onset systemic lupus erythematosus: a comparative study

  • Miguel Ángel Saavedra
  • Dafhne Miranda-Hernández
  • Antonio Sánchez
  • Sara Morales
  • Pilar Cruz-Domínguez
  • Gabriela Medina
  • Luis Javier Jara
Women Issues
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Accepted:

Abstract

To compare the maternal and fetal outcomes between childhood-onset and adult-onset systemic lupus erythematosus (SLE), we reviewed the medical records of SLE pregnant women treated from January 2005 to August 2013. For comparison, patients were allocated to one of the two groups, those pregnant patients with SLE onset before 18 years of age (childhood-onset) and ≥18 years (adult-onset). The patients were evaluated at least once in each trimester and postpartum. Relevant maternal and fetal outcomes were extracted, such as lupus flare, preeclampsia/eclampsia, rate of liveborns, fetal loss (spontaneous abortion and stillbirth), term delivery, preterm birth, neonatal death, low birth weight, low birth weight at term, and congenital malformations. We studied 186 pregnancies (in 180 women), 58 of them had childhood-onset SLE, and the remaining 128 had adult-onset SLE. The rate of maternal and fetal complications was similar in both groups. Multivariate analysis showed that active SLE before pregnancy, primigravida, renal flare, preeclampsia, lupus flare, anticardiolipin antibodies, and low serum complement were associated with an increased risk of poor maternal and fetal outcomes. The diagnosis of childhood-onset had no impact on maternal–fetal outcome. The maternal and fetal outcome in women with childhood-onset SLE is similar to that reported in women with adult-onset SLE. Pregnancy in women with childhood-onset SLE should not be contraindicated if the disease is well controlled.

Keywords

Pregnancy Maternal–fetal outcome Systemic lupus erythematosus Childhood-onset lupus 
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Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Miguel Ángel Saavedra
    • 1
  • Dafhne Miranda-Hernández
    • 1
  • Antonio Sánchez
    • 1
  • Sara Morales
    • 2
  • Pilar Cruz-Domínguez
    • 3
  • Gabriela Medina
    • 4
  • Luis Javier Jara
    • 5
  1. 1.Rheumatology Department, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialMexico CityMexico
  2. 2.Perinatology Department, Hospital de Gineco-Obstetricia No. 3, Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialMexico CityMexico
  3. 3.Division of Investigation, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialMexico CityMexico
  4. 4.Clinical Research Unit, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialMexico CityMexico
  5. 5.Direction of Education and Research, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La RazaInstituto Mexicano del Seguro SocialMexico CityMexico

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