Rheumatology International

, Volume 35, Issue 1, pp 159–166 | Cite as

Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia impact questionnaire score: a meta-analysis

Original Article

Abstract

The aim of this study was to explore whether the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with susceptibility to fibromyalgia and fibromyalgia impact questionnaire (FIQ) score in fibromyalgia patients. We conducted a meta-analysis of the associations of the COMT Val158Met polymorphism with fibromyalgia risk as well as FIQ score in fibromyalgia patients. A total of 993 fibromyalgia patients and 778 controls from 10 studies on the COMT Val158Met polymorphism and 538 fibromyalgia patients from 5 studies on the COMT Val158Met polymorphism and FIQ score were included in this meta-analysis. The meta-analysis revealed an association between fibromyalgia and the COMT Met/Met + Val/Met genotype in all study subjects (odds ratio (OR) 1.635, 95 % confidence interval (CI) 1.029–2.597, p = 0.037). However, stratification by ethnicity indicated no association between the Met/Met + Val/Met genotype and fibromyalgia in the European and Turkish populations (OR 1.202, 95 % CI 0.876–1.649, p = 0.255; OR 2.132, 95 % CI 0.764–5.949, p = 0.148, respectively). Analysis using other genetic models showed no association between the COMT Val158Met polymorphism and fibromyalgia. The meta-analysis also revealed that the FIQ score was significantly higher in individuals with the COMT Met/Met genotype than in those with the Val/Val genotype [weighted mean difference (WMD) = 14.39, 95 % CI 3.316–25.48, p = 0.011] and the Val/Met genotype (WMD = 5.108, 95 % CI 2.212–4.891, p = 0.021). This meta-analysis identified an association between fibromyalgia risk and the COMT Val158Met polymorphism as well as the FIQ score in fibromyalgia patients.

Keywords

Fibromyalgia COMT Polymorphism Meta-analysis 

References

  1. 1.
    Neumann L, Buskila D (2003) Epidemiology of fibromyalgia. Curr Pain Headache Rep 7(5):362–368PubMedCrossRefGoogle Scholar
  2. 2.
    Wallace DJ, Linker-Israeli M, Hallegua D, Silverman S, Silver D, Weisman MH (2001) Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology 40(7):743–749PubMedCrossRefGoogle Scholar
  3. 3.
    Buskila D, Sarzi-Puttini P (2006) Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. Arthritis Res Ther 8(5):218PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    Lee YH, Choi SJ, Ji JD, Song GG (2012) Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. Rheumatol Int 32(2):417–426Google Scholar
  5. 5.
    Kaenmaki M, Tammimaki A, Myohanen T, Pakarinen K, Amberg C, Karayiorgou M et al (2010) Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice. J Neurochem 114(6):1745–1755PubMedCrossRefGoogle Scholar
  6. 6.
    Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM (1996) Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6(3):243–250PubMedCrossRefGoogle Scholar
  7. 7.
    Martinez-Jauand M, Sitges C, Rodriguez V, Picornell A, Ramon M, Buskila D et al (2013) Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene. Eur J Pain 17(1):16–27PubMedCrossRefGoogle Scholar
  8. 8.
    Desmeules J, Piguet V, Besson M, Chabert J, Rapiti E, Rebsamen M et al (2012) Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism. Health Psychol 31(2):242–249PubMedCrossRefGoogle Scholar
  9. 9.
    Matsuda JB, Barbosa FR, Morel LJ, de Castro Franca S, Zingaretti SM, da Silva LM et al (2010) Serotonin receptor (5-HT 2A) and catechol-O-methyltransferase (COMT) gene polymorphisms: triggers of fibromyalgia? Rev Bras Reumatol 50(2):141–149PubMedCrossRefGoogle Scholar
  10. 10.
    Cohen H, Neumann L, Glazer Y, Ebstein RP, Buskila D (2009) The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia. Clin Exp Rheumatol 27(5 Suppl 56):S51–S56PubMedGoogle Scholar
  11. 11.
    Potvin S, Larouche A, Normand E, de Souza JB, Gaumond I, Grignon S et al (2009) DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls. J Pain 10(9):969–975PubMedCrossRefGoogle Scholar
  12. 12.
    Tander B, Gunes S, Boke O, Alayli G, Kara N, Bagci H et al (2008) Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatol Int 28(7):685–691PubMedCrossRefGoogle Scholar
  13. 13.
    Vargas-Alarcon G, Fragoso JM, Cruz-Robles D, Vargas A, Vargas A, Lao-Villadoniga JI et al (2007) Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. Arthritis Res Ther 9(5):R110PubMedCentralPubMedCrossRefGoogle Scholar
  14. 14.
    Gursoy S, Erdal E, Herken H, Madenci E, Alasehirli B, Erdal N (2003) Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome. Rheumatol Int 23(3):104–107PubMedGoogle Scholar
  15. 15.
    Fernandez-de-las-Penas C, Penacoba-Puente C, Cigaran-Mendez M, Diaz-Rodriguez L, Rubio-Ruiz B, Arroyo-Morales M (2014) Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome? Clin J Pain 30(3):199–204PubMedCrossRefGoogle Scholar
  16. 16.
    Barbosa FR, Matsuda JB, Mazucato M, de Castro Franca S, Zingaretti SM, da Silva LM et al (2012) Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients. Rheumatol Int 32(2):427–430PubMedCrossRefGoogle Scholar
  17. 17.
    Finan PH, Zautra AJ, Davis MC, Lemery-Chalfant K, Covault J, Tennen H (2011) COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia. Pain 152(2):300–307PubMedCentralPubMedCrossRefGoogle Scholar
  18. 18.
    Garcia-Fructuoso FJ, Lao-Villadoniga JI, Beyer K, Santos C (2006) Relationship between COMT gene genotypes and severity of fibromyalgia. Reumatol Clin 2(4):168–172CrossRefGoogle Scholar
  19. 19.
    Lee YH, Rho YH, Choi SJ, Ji JD, Song GG (2007) PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis. Rheumatol Int 27(9):827–833PubMedCrossRefGoogle Scholar
  20. 20.
    Lee YH, Woo JH, Choi SJ, Ji JD, Song GG (2010) Associations between osteoprotegerin polymorphisms and bone mineral density: a meta-analysis. Mol Biol Rep 37(1):227–234Google Scholar
  21. 21.
    Lee YH, Bae SC, Choi SJ, Ji JD, Song GG (2011) Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep 38(6):3643–3651PubMedCrossRefGoogle Scholar
  22. 22.
    Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558PubMedCrossRefGoogle Scholar
  23. 23.
    DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188PubMedCrossRefGoogle Scholar
  24. 24.
    Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634PubMedCentralPubMedCrossRefGoogle Scholar
  25. 25.
    Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG (2001) Replication validity of genetic association studies. Nat Genet 29(3):306–309PubMedCrossRefGoogle Scholar
  26. 26.
    Tammimaki A, Mannisto PT (2012) Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis. Pharmacogenet Genomics 22(9):673–691PubMedCrossRefGoogle Scholar
  27. 27.
    Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE et al (2001) Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98(12):6917–6922PubMedCentralPubMedCrossRefGoogle Scholar
  28. 28.
    Nackley AG, Tan KS, Fecho K, Flood P, Diatchenko L, Maixner W (2007) Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain 128(3):199–208PubMedCrossRefGoogle Scholar
  29. 29.
    Riva R, Mork PJ, Westgaard RH, Okkenhaug Johansen T, Lundberg U (2012) Catecholamines and heart rate in female fibromyalgia patients. J Psychosom Res 72(1):51–57PubMedCrossRefGoogle Scholar
  30. 30.
    Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y et al (2003) COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science 299(5610):1240–1243PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Rheumatology, Department of Internal Medicine, Korea University Anam HospitalKorea University College of MedicineSeoulKorea

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