Rheumatology International

, Volume 34, Issue 5, pp 637–642 | Cite as

Screening for celiac disease, by endomysial antibodies, in patients with unexplained articular manifestations

  • Mariam Ghozzi
  • Wahiba Sakly
  • Amani Mankaï
  • Elyes Bouajina
  • Fethi Bahri
  • Rafiaa Nouira
  • Chedia Kechrid
  • Ibtissem Ghedira
Original Article


Celiac disease (CD) is an autoimmune systemic disease characterized by not only gastrointestinal but also extraintestinal manifestations. The aim of our study was to do a serological screening for CD, by IgA endomysial antibodies (EmA), in patients with unexplained articular manifestations. Two hundred and eleven patients suffering from arthritis or arthralgia without evident cause were studied. EmA were determined by indirect immunofluorescence on human umbilical cord. Two thousand and five hundred blood donors served as control group. Out of 211 patients, 5 had EmA (2.37 %). The frequency of EmA in our patients was significantly higher than in the control group (2.37 vs. 0.28 %, p < 0.01). All patients with positive EmA were female. EmA were significantly more frequent in female patients than in female healthy subjects (3 vs. 0.4 %, p < 0.01). Medical records revealed: diarrhea (one patient), short size (one patient), anemia (three patients), weight loss (two patients) spontaneous abortion (three patients), secondary amenorrhea (one patient), early menopause (one patient) and early baby death (one patient). Biochemical analysis showed decreased level of calcium (one patient), vitamin D (one patient) and cholesterol (one patient). Unexplained liver cytolysis was observed in two patients. Radiological examination showed demineralization of two hands in one patient. Bone osteodensitometry done in one patient out of five revealed lumbar osteopenia. The articular manifestations of the five patients did not respond to corticosteroid treatment. CD must be considered among the differential diagnosis in a patient with arthritis or arthralgia.


Arthritis Arthralgia Endomysial antibodies Celiac disease Adults 



This study is supported by: Unité de recherche: Auto-immunité et Allergie (03/UR/07-02), Faculté de Pharmacie de Monastir, Tunisia.

Conflict of interest

None of the authors have conflicts of interest to declare.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Mariam Ghozzi
    • 1
  • Wahiba Sakly
    • 2
  • Amani Mankaï
    • 2
    • 3
  • Elyes Bouajina
    • 4
  • Fethi Bahri
    • 5
  • Rafiaa Nouira
    • 6
  • Chedia Kechrid
    • 7
  • Ibtissem Ghedira
    • 1
    • 2
    • 8
  1. 1.Department of ImmunologyFarhat Hached University HospitalSousseTunisia
  2. 2.Research Unit (03/UR/07-02), Faculty of PharmacyMonastir UniversityMonastirTunisia
  3. 3.High School of Sciences and Techniques of HealthTunis el Manar UniversityTunisTunisia
  4. 4.Department of RheumatologyFarhat Hached University HospitalSousseTunisia
  5. 5.Department of Internal MedicineFarhat Hached University HospitalSousseTunisia
  6. 6.Department of DermatologyFarhat Hached University HospitalSousseTunisia
  7. 7.Department of Internal MedicineSahloul University HospitalSousseTunisia
  8. 8.Laboratory of ImmunologyFarhat Hached HospitalSousseTunisia

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