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Rheumatology International

, Volume 33, Issue 10, pp 2539–2542 | Cite as

A study on the association between C1GALT1 polymorphisms and the risk of Henoch–Schönlein purpura in a Chinese population

  • JinDan An
  • Qiang Lü
  • HongTao Zhao
  • Yong Cao
  • Bin Yan
  • Zhihong MaEmail author
Original Article

Abstract

Henoch–Schönlein purpura (HSP) is the most common systemic vasculitis of childhood. The molecular etiology of HSP is not well understood. The purpose of this study is to investigate the association between polymorphisms in C1GALT1 gene and the risk of HSP in a Chinese population. A total of unrelated 542 northern Chinese were enrolled in this study. PCR-RFLP method was used to genotype the five tagging SNPs in the C1GALT1 gene. Chi-squared test and logistic regression analysis were used for the comparison of genotype distribution between cases and controls. The five tagging SNPs were all in Hardy–Weinberg equilibrium in controls. SNP7 was significantly associated with HSP risk, P = 0.005. The DI genotype, compared with the DD genotype, was associated with a significantly higher risk of developing HSP (OR 1.72; 95 % CI 1.11–2.67). The II genotype, compared with the DD genotype, was associated with a significantly higher risk of developing HSP (OR 3.39; 95 % CI 1.16–9.30). Other SNPs were not associated with HSP risk. Variations in the C1GALT1 gene were found to be associated with HSP risk. Further studies are warranted to validate our findings and to investigate into its underlining mechanism.

Keywords

HSP Case–control study SNP C1GALT1 

Notes

Acknowledgments

This study was supported by Foundation for University Key Teacher of Heilongjiang Province of China (No. 1252G066).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • JinDan An
    • 1
    • 2
  • Qiang Lü
    • 1
  • HongTao Zhao
    • 3
  • Yong Cao
    • 2
  • Bin Yan
    • 2
  • Zhihong Ma
    • 4
  1. 1. Key Laboratory of Cancer Prevention and Treatment of Heilongjiang ProvinceMudanjiang Medical UniversityMudanjiangChina
  2. 2.Department of PathologyMudanjiang Medical UniversityMudanjiangChina
  3. 3.Department of PhysiopathologyMudanjiang Medical UniversityMudanjiangChina
  4. 4.Department of DermatologyThe HongQi Affiliated Hospital of Mudanjiang Medical UniversityMudanjiangChina

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