Rheumatology International

, Volume 33, Issue 8, pp 1991–1999 | Cite as

The PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis

  • Gwan Gyu Song
  • Sang-Cheol Bae
  • Jae-Hoon Kim
  • Young Ho LeeEmail author
Original Article


The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. MEDLINE database and manual search were utilized to identify articles in which the PTPN22 polymorphism was determined in RA patients and controls. A meta-analysis was conducted on the associations between the PTPN22 C1858T polymorphism and RA using (1) allelic contrast and (2) dominant model. A total of 30 separate comparisons involving 17,961 RA patients and 18,611 controls were considered in this meta-analysis. Meta-analysis showed an association between the T allele and RA in all subjects (OR = 1.490, 95 % CI = 1.332–1.668, P < 1.0 × 10−9). After stratification by ethnicity, analysis indicated that the T allele was significantly associated with RA in Europeans and in Non-Europeans (OR = 1.423, 95 % CI = 1.260–1.605, P = 1.0 × 10−8; OR = 1.902, 95 % CI = 1.488–2.430, P = 2.8 × 10−8). Meta-analysis of the CT + TT genotype showed the same result patterns as that shown by the PTPN22 C1858T polymorphism T allele. Furthermore, a direct comparison between rheumatoid factor (RF)-positive and RF-negative subjects revealed a significant association with the T allele in RA patients with RF, but not in subjects without RF (OR = 1.561, 95 % CI = 1.373–1.775, P < 1.0 × 10−9). This meta-analysis confirms that the PTPN22 C1858T polymorphism is associated with RA susceptibility in different ethnic groups, especially in Europeans, and the PTPN22 C1858T polymorphism T allele is significantly more prevalent in RF-positive patents than in RF-negative patients.


Protein tyrosine phosphatase nonreceptor 22 Polymorphism Rheumatoid arthritis Meta-analysis 



This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).

Conflict of interest

We have no financial and nonfinancial conflicts of interest.

Supplementary material

296_2013_2679_MOESM1_ESM.doc (40 kb)
Supplementary material 1 (DOC 39 kb)
296_2013_2679_MOESM2_ESM.doc (74 kb)
Supplementary material 2 (DOC 73 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Gwan Gyu Song
    • 1
  • Sang-Cheol Bae
    • 2
  • Jae-Hoon Kim
    • 1
  • Young Ho Lee
    • 1
    Email author
  1. 1.Division of Rheumatology, Department of Internal Medicine, Korea University Anam HospitalKorea University College of MedicineSeoulKorea
  2. 2.The Hospital for Rheumatic DiseasesHanyang University Medical CenterSeoulKorea

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