Advertisement

Rheumatology International

, Volume 33, Issue 10, pp 2455–2458 | Cite as

Efficacy of infliximab in the treatment for dermatomyositis with acute interstitial pneumonia: a study of fourteen cases and literature review

  • Dan Chen
  • Xiao-bing Wang
  • Yan Zhou
  • Xiao-chun ZhuEmail author
Review

Abstract

This retrospective study assessed the efficacy of infliximab therapy in 14 patients with dermatomyositis with acute interstitial pneumonia. Ten patients starting treatment at an early stage of the disease achieved satisfactory relief, while four patients treated at a late stage failed to respond to the treatment and died.

Keywords

Dermatomyositis Acute interstitial pneumonia Treatment Infliximab 

Abbreviations

AIP

Acute interstitial pneumonia

AST

Aspartate aminotransferase

CADM

Clinical amyopathic dermatomyositis

CKP

Creatine phosphokinase

CRP

C-reactive protein

CT

Computed tomography

DM

Dermatomyositis

DM-ILD

Dermatomyositis complicated with interstitial lung disease

IFX

Infliximab

IgG

Immunoglobulin G

ILD

Interstitial lung disease

LDH

Lactate dehydrogenase

PaO2

Arterial partial pressure of oxygen

PA-aO2

Alveolar-arterial oxygen tension difference

References

  1. 1.
    Ye S, Chen XX, Lu XY et al (2007) Adult clinically amyopathic dermatomyositis with rapid progressive interstitial lung disease: a retrospective cohort study. Clin Rheumatol 26:1647–1654PubMedCrossRefGoogle Scholar
  2. 2.
    Santmyire-Rosenberger B, Dugan EM (2003) Skin involvement in dermatomyositis. Curr Opin Rheumatol 15:714–722PubMedCrossRefGoogle Scholar
  3. 3.
    Yoshinari D, Takeyoshi I, Koibuchi Y et al (2001) Effects of a dual inhibitor of TNF-α and IL-1 on lipopolysaccharide-induced lung injury in rats. Crit Care 5: P083–S39Google Scholar
  4. 4.
    Hassan AB, Nikitina-Zake L, Sanjeevi CB et al (2004) Association of the proinflammatory haplotype (MICA5.1/TNF2/TNFa2/DRB1*03)with polymyositis and dermatomyositis. Arthr Rheumatol 50:1013–1015CrossRefGoogle Scholar
  5. 5.
    Fathi M, Dastmalchi M, Rasmussen E et al (2004) Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis. Ann Rheumatol Dis 63:297–301CrossRefGoogle Scholar
  6. 6.
    Wei QH, Jin YL, Yang HT et al (2007) Clinical analysis of 7 dermatomyositis cases with acute interstitial pneumonia and literature review. Clin J Rheumatol 11:301–303Google Scholar
  7. 7.
    Kameda H, Nagasawa H, Oqawa H et al (2005) Combination therapy with corticosteroids, cyclosporine A, and intravenous pulse cyclophosphamide for acute/subacute interstitial pneumonia in patients with dermatomyositis. Rheumatology 32:1719–1726Google Scholar
  8. 8.
    Hengstman GJD, van den Hoogen FHJ, van Engelen BGM (2009) Treatment of the inflammatory myopathies: update and practical recommendations. Expert Opin Pharmacother 10:1183–1190PubMedCrossRefGoogle Scholar
  9. 9.
    Takahisa G, Yasushi K, Takashi S et al (2010) Clinical manifestation and prognostic factor in anti-melanoma differentiation-associated gene 5 antibody-associated interstitial lung disease as a complication of dermatomyositis. Rheumatology 49:1713–1719CrossRefGoogle Scholar
  10. 10.
    Ji SY, Zeng FQ, Guo Q et al (2010) Predictive factors and unfavourable prognostic factors of interstitial lung disease in patients with polymyositis or dermatomyositis: a retrospective study. Chin Med J Engl 123:517–522PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Dan Chen
    • 1
  • Xiao-bing Wang
    • 1
  • Yan Zhou
    • 1
  • Xiao-chun Zhu
    • 1
    Email author
  1. 1.Division of Rheumatology, First Affiliated HospitalWenzhou Medical CollegeZhejiangChina

Personalised recommendations