Rheumatology International

, Volume 34, Issue 1, pp 145–147

Cryoglobulinemic vasculitis in systemic sclerosis successfully treated with mycophenolate mofetil

Short Communication

DOI: 10.1007/s00296-012-2640-9

Cite this article as:
Ostojic, P. Rheumatol Int (2014) 34: 145. doi:10.1007/s00296-012-2640-9


Cryoglobulinemic vasculitis is extremely rare in patients with systemic sclerosis (SSc). So far, only two cases of cryoglobulinemic vasculitis in SSc were described in the literature. This report is about a patient with SSc and secondary Sjőgren’s syndrome, who developed typical clinical features of small-vessel vasculitis, including arthritis, purpura, microhaematuria, gangrene of fingers, and toes and myocardial ischemia, in the presence of mixed cryoglobulinemia, ANA, rheumatoid factor, and anti-SSA/Ro antibodies. Symptoms and signs of vasculitis worsened despite initial treatment with corticosteroids and cyclophosphamide, but improved significantly when mycophenolate mofetil was used instead cyclophosphamide.


Systemic sclerosis Cryoglobulinemia Vasculitis 

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.School of Medicine, Institute of RheumatologyUniversity of BelgradeBelgradeSerbia

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