Rheumatology International

, Volume 34, Issue 1, pp 145–147

Cryoglobulinemic vasculitis in systemic sclerosis successfully treated with mycophenolate mofetil

Short Communication

DOI: 10.1007/s00296-012-2640-9

Cite this article as:
Ostojic, P. Rheumatol Int (2014) 34: 145. doi:10.1007/s00296-012-2640-9

Abstract

Cryoglobulinemic vasculitis is extremely rare in patients with systemic sclerosis (SSc). So far, only two cases of cryoglobulinemic vasculitis in SSc were described in the literature. This report is about a patient with SSc and secondary Sjőgren’s syndrome, who developed typical clinical features of small-vessel vasculitis, including arthritis, purpura, microhaematuria, gangrene of fingers, and toes and myocardial ischemia, in the presence of mixed cryoglobulinemia, ANA, rheumatoid factor, and anti-SSA/Ro antibodies. Symptoms and signs of vasculitis worsened despite initial treatment with corticosteroids and cyclophosphamide, but improved significantly when mycophenolate mofetil was used instead cyclophosphamide.

Keywords

Systemic sclerosis Cryoglobulinemia Vasculitis 

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.School of Medicine, Institute of RheumatologyUniversity of BelgradeBelgradeSerbia

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