Efficacy and safety of oral low-dose glucocorticoids in patients with estrogen-dependent primary osteoarthritis
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Estrogen-dependent osteoarthritis (EDPOA) is a disease of perimenopausal-age women. Their manifestations are polyarticular pain with common co-morbidities (carpal tunnel syndrome, insomnia, fatigue, depression, and fibromyalgia). Based on dual role of glucocorticoids, its trophic action on the chondrocyte and its anti-inflammatory effect, we conducted a prospective interventional cohort study where we evaluate the efficacy and safety of oral low-dose GC in one hundred women with EDPOA. The pain intensity, number of tender joints as well as impact in co-morbidities were analyzed. We conclude that the use of low-dose GC in patients with EDPOA can be an effective and a safe therapeutic option.
KeywordsPrimary osteoarthritis Glucocorticoids Steroids Menopause
We would like to thank the Fundación Valle del Lili to facilitate this work. We would also like to acknowledge Marisol Badiel M.D. for critical review of the article and his contributions to the statistical analysis.
Conflict of interest
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