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Rheumatology International

, Volume 34, Issue 5, pp 733–735 | Cite as

Efficacy and safety of oral low-dose glucocorticoids in patients with estrogen-dependent primary osteoarthritis

  • Carlos A. Cañas
  • Carlos J. Osorio
  • Nicolás Coronel
  • Magda C. Cepeda
  • Jorge H. Izquierdo
  • Fabio Bonilla-Abadía
Short Communication

Abstract

Estrogen-dependent osteoarthritis (EDPOA) is a disease of perimenopausal-age women. Their manifestations are polyarticular pain with common co-morbidities (carpal tunnel syndrome, insomnia, fatigue, depression, and fibromyalgia). Based on dual role of glucocorticoids, its trophic action on the chondrocyte and its anti-inflammatory effect, we conducted a prospective interventional cohort study where we evaluate the efficacy and safety of oral low-dose GC in one hundred women with EDPOA. The pain intensity, number of tender joints as well as impact in co-morbidities were analyzed. We conclude that the use of low-dose GC in patients with EDPOA can be an effective and a safe therapeutic option.

Keywords

Primary osteoarthritis Glucocorticoids Steroids Menopause 

Notes

Acknowledgments

We would like to thank the Fundación Valle del Lili to facilitate this work. We would also like to acknowledge Marisol Badiel M.D. for critical review of the article and his contributions to the statistical analysis.

Conflict of interest

None.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Carlos A. Cañas
    • 1
  • Carlos J. Osorio
    • 2
  • Nicolás Coronel
    • 3
  • Magda C. Cepeda
    • 4
  • Jorge H. Izquierdo
    • 1
  • Fabio Bonilla-Abadía
    • 1
  1. 1.Rheumatology Unit, Fundación Valle del LiliICESI UniversityCaliColombia
  2. 2.Internal Medicine Department, Fundación Valle del LiliICESI UniversityCaliColombia
  3. 3.Internal Medicine Department, Fundación Valle del LiliCES UniversityCaliColombia
  4. 4.Instituto de Investigaciones ClínicasFundación Valle del LiliCaliColombia

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