Advertisement

Rheumatology International

, Volume 33, Issue 5, pp 1219–1222 | Cite as

The prevalence of fibromyalgia in patients with Behçet’s disease and its relation with disease activity

  • Mehmet MelikogluEmail author
  • Meltem Alkan Melikoglu
Original Article

Abstract

Behçet’s disease (BD) is a chronic disorder characterized by mucocutaneous and multisystem manifestations. Fibromyalgia (FM) is characterized by widespread musculoskeletal pain and may be present concomitantly with several rheumatic diseases. Our aims were to investigate the prevalence of FM in patients with BD and to evaluate the possible relation of FM presence with BD disease activity. A total of 104 Behcet patients were included in this study. Age, sex, disease durations and the BD Current Activity Form (BDCAF) scores as disease activity evaluation were recorded. Presence of FM and the Fibromyalgia Impact Questionnaire (FIQ) scores was investigated. Also, ESR and CRP concentrations were determined in all patients. Mann–Whitney U test and Pearson’s correlation tests were used for the statistical analysis. There were 60 female and 40 male patients with an age range of 19–51 years. Eighteen of 100 BD patients were diagnosed as FM. Although ages, disease duration and laboratory parameters did not differ between BD patients with and without FM, BD patients with FM were more frequently female (p < 0.000). The presence of FM did not differ significantly between patients with and without systemic manifestations. Also, oral–genital ulcers, erythema nodosum, thrombophlebitis, pustular lesions and doctor’s impression of disease activity scores were not found to be different in BD patients with or without FM. However, there were significant differences in fatigue, headache, arthralgia and patient impression of disease activity (today and last 28 days) between these groups (p < 0.000; p < 0.01; p < 0.01; p = 0.021 and p = 0.027, respectively). Also, there were significant correlations between BDCAF and FIQ items that refer pain and fatigue (p < 0.01). FM is a common and important clinical problem that may represent an additional factor that worsens pain and physical limitations in patients with BD. The higher prevalence of FM in patients with BD seems to be affected by BD itself, rather than its severity.

Keywords

Behçet’s disease Fibromyalgia Disease activity 

References

  1. 1.
    Sakene T, Takeno M, Suzuki N, Inaba G (1999) Behçet’s disease. N Engl J Med 341:1284–1291CrossRefGoogle Scholar
  2. 2.
    Yurdakul S, Yazici H, Tüzün Y, Pazarli H, Yalçin B, Altaç M, Ozyazgan Y, Tüzüner N, Müftüoğlu A (1983) The arthritis of Behçet’s disease: a prospective study. Ann Rheum Dis 42:505–515PubMedCrossRefGoogle Scholar
  3. 3.
    Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L (1995) The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 38:19–28PubMedCrossRefGoogle Scholar
  4. 4.
    Ediz L, Hiz O, Toprak M, Tekeoglu I, Ercan S (2011) The validity and reliability of the Turkish version of the Revised Fibromyalgia Impact Questionnaire. Clin Rheumatol 30:339–346PubMedCrossRefGoogle Scholar
  5. 5.
    Wolfe F, Michaud K (2004) Severe rheumatoid arthritis (RA), worse outcomes, comorbid illness, and sociodemographic disadvantage characterize ra patients with fibromyalgia. J Rheumatol 31:695–700PubMedGoogle Scholar
  6. 6.
    Naranjo A, Ojeda S, Francisco F, Erausquin C, Rúa-Figueroa I, Rodríguez-Lozano C (2002) Fibromyalgia in patients with rheumatoid arthritis is associated with higher scores of disability. Ann Rheum Dis 61:660–661PubMedCrossRefGoogle Scholar
  7. 7.
    Torrente-Segarra V, Carbonell-Abelló J, Castro-Oreiro S, Manresa Domínguez JM (2010) Association between fibromyalgia and psychiatric disorders in systemic lupus erythematosus. Clin Exp Rheumatol 28:S22–S26PubMedGoogle Scholar
  8. 8.
    International Study Group for Behcet’s Disease (1990) Criteria for the diagnosis of Behcet’s Disease. Lancet 335:1078–1080Google Scholar
  9. 9.
    Bhakta BB, Brennan P, James TE, Chamberlain MA et al (1999) Behçet’s disease: evaluation of a new instrument to measure clinical activity. Rheumatology 38:728–733PubMedCrossRefGoogle Scholar
  10. 10.
    Hamuryudan V, Fresko İ, Direskeneli H, Tennant MJ et al (1999) Evaluation of the Turkish translation of a disease activity form for Behçet’s syndrome. Rheumatology 38:734–736PubMedCrossRefGoogle Scholar
  11. 11.
    Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the Multicenter Criteria Committee. Arthritis Rheum 33:160–172PubMedCrossRefGoogle Scholar
  12. 12.
    Sarmer S, Ergin S, Yavuzer G (2000) The validity and reliability of the Turkish version of the Fibromyalgia Impact Questionnaire. Rheumatol Int 20:9–12PubMedCrossRefGoogle Scholar
  13. 13.
    Burckhardt CS, Clark SR, Bennett RM (1991) The fibromyalgia impact questionnaire: development and validation. J Rheumatol 18:728–733PubMedGoogle Scholar
  14. 14.
    Middleton GD, McFarlin JE, Lipsky PE (1994) The prevalence and clinical impact of Fibromyalgia in systemic lupus erythematosus. Arthritis Rheum 37:1181–1188PubMedCrossRefGoogle Scholar
  15. 15.
    Buskila D, Press J, Abu-Shakra M (2003) Fibromyalgia in systemic lupus erythematosus: prevalence and clinical implications. Clin Rev Allergy Immunol 25:25–28PubMedCrossRefGoogle Scholar
  16. 16.
    Buskila D, Langevitz P, Gladman DD, Urowitz S, Smythe HA (1992) Patients with rheumatoid arthritis are tenderer than those with psoriatic arthritis. J Rheumatol 19:1115–1119PubMedGoogle Scholar
  17. 17.
    Buskila D, Odes LR, Neumann L, Odes HS (1999) Fibromyalgia in Inflammatory bowel disease. J Rheumatol 26:1167–1171PubMedGoogle Scholar
  18. 18.
    Aloush V, Ablin JN, Reitblat T, Caspi D, Elkayam O (2007) Fibromyalgia in women with ankylosing spondylitis. Rheumatol Int 27:865–868PubMedCrossRefGoogle Scholar
  19. 19.
    Arnold LM, Clauw DJ, McCarberg BH (2011) Improving the recognition and diagnosis of fibromyalgia. Mayo Clin Proc 86:457–464PubMedCrossRefGoogle Scholar
  20. 20.
    Al-Izzi MK, Jabber AS (2004) Fibromyalgia in Iraqi patients with Behcet’s disease. J Med Liban 52:86–90PubMedGoogle Scholar
  21. 21.
    Lee SS, Yoon HJ, Chang HK, Park KS (2005) Fibromyalgia in Behçet’s disease is associated with anxiety and depression, and not with disease activity. Clin Exp Rheumatol 23:15–19Google Scholar
  22. 22.
    Yavuz S, Fresko I, Hamuryudan V, Yurdakul S, Yazici H (1998) Fibromyalgia in Behçet’s syndrome. J Rheumatol 25:2219–2220PubMedGoogle Scholar
  23. 23.
    Akkuş S, Senol A, Ayvacioglu NB, Tunc E, Eren I, Isler M (2004) Is female predominance in irritable bowel syndrome related to fibromyalgia? Rheumatol Int 24:106–109PubMedCrossRefGoogle Scholar
  24. 24.
    Melikoglu MA, Melikoglu M (2010) The relationship between disease activity and depression in patients with Behcet disease and rheumatoid arthritis. Rheumatol Int 30:941–946PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of DermatologyMinistry of Health Erzurum Regional Training and Research HospitalErzurumTurkey
  2. 2.Physical Medicine and Rehabilitation, Rheumatology Department, Medical FacultyAtaturk UniversityErzurumTurkey

Personalised recommendations