Advertisement

Rheumatology International

, Volume 33, Issue 5, pp 1159–1163 | Cite as

Health-related quality of life in Turkish patients with Ankylosing spondylitis: impact of peripheral involvement on quality of life in terms of disease activity, functional status, severity of pain, and social and emotional functioning

  • Özlem Yılmaz
  • Ahmet Tutoğlu
  • Yeşim Garip
  • Esra Özcan
  • Hatice Bodur
Original Article

Abstract

Ankylosing spondylitis (AS) affects sacroiliac joints at early stages and may involve the axial skeleton at later stages of disease. Peripheral involvement usually occurs in lower extremities. When it develops early in the disease course, it is a predictor of more aggressive disease. The aim of this study is to evaluate health-related quality of life (HRQoL) in AS and to assess the impact of peripheral involvement on HRQoL domains in terms of disease activity, functional status, pain, and social and emotional functioning. Seventy-four AS patients were included. Peripheral involvement was present in 51.35 % of the patients. In 65.79 % of these cases the hips, in 31.58 % the knees, in 18.42 % the shoulders and in 13.16 % the ankles were affected. Patients were evaluated by Ankylosing Spondylitis Quality of Life (ASQoL), Short Form-36 (SF-36), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS) and Bath Ankylosing Spondylitis Functional Index (BASFI). ASQoL was strongly correlated with ASDAS, BASDAI, BASFI, and Bath Ankylosing Spondylitis Metrology Index (BASMI), severity of total pain, night pain, fatigue, morning stiffness and ESR. ASDAS and BASDAI showed the strongest correlation with ASQoL. Severity of total pain, functional status and severity of night pain followed it, respectively. Patients with peripheral involvement scored significantly lower in all subgroups of SF36 and significantly higher in ASDAS, BASDAI, BASFI, BASMI and ASQoL scores and levels of pain, night pain, fatigue and morning stiffness. Peripheral involvement is associated with more active disease and functional disability and has a negative influence on HRQoL including physical, social and emotional functioning.

Keywords

Ankylosing spondylitis (AS) Peripheral arthritis Peripheral involvement Health-related quality of life (HRQoL) Ankylosing spondylitis disease activity score (ASDAS) Ankylosing spondylitis quality of life score (ASQoL) 

References

  1. 1.
    Van der Linden SM, Van der Heijde D, Maksymowych WP (2009) Ankylosing spondylitis. In: Firestein GS, Budd RC, Harris ED et al. Kelley’s textbook of rheumatology. 8th ed., Saunders Elsevier, Philadelphia, pp 1169–1190Google Scholar
  2. 2.
    Gensler L (2011) Clinical features of ankylosing spondylitis. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH (eds) Rheumatology, 5th edn. Mosby Elsevier, Philadelphia, pp 1129–1134CrossRefGoogle Scholar
  3. 3.
    Ward MM (1998) Quality of life in patients with ankylosing spondylitis. Rheum Dis Clin North Am 24:815–827PubMedCrossRefGoogle Scholar
  4. 4.
    Bostan EE, Borman P, Bodur H, Barça N (2003) Functional disability and quality of life in patients with ankylosing spondylitis. Rheumatol Int 23:121–126PubMedGoogle Scholar
  5. 5.
    Moll JM (1987) New criteria for the diagnosis of ankylosing spondylitis. Scand J Rheumatol Suppl 65:12–24PubMedCrossRefGoogle Scholar
  6. 6.
    Sieper J, Rudwaleit M, Baraliakos X, Brandt J, Braun J (2009) The Assessment of SpondyloArthritis International Society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis 68:1–44Google Scholar
  7. 7.
    Akkoc Y, Karatepe AG, Akar S, Kirazli Y, Akkoc N (2005) A Turkish version of the Bath Ankylosing Spondylitis Disease Activity Index: reliability and validity. Rheumatol Int 25:280–284PubMedCrossRefGoogle Scholar
  8. 8.
    Machado P, van der Heijde D (2011) How to measure disease activity in axial spondyloarthritis. Curr Opin Rheumatol 23:339–345PubMedCrossRefGoogle Scholar
  9. 9.
    Calin A, Garrett S, Whitelock H et al (1994) A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 21:2281–2285PubMedGoogle Scholar
  10. 10.
    Duruoz T, Doward L, Cerrahoglu L et al (2008) Translation and validation of the Turkish version of the ankylosing spondylitis quality of life (ASQoL) Questionnaire. EULAR 2008 Abstract Book, Paris, 11–14 June 2008Google Scholar
  11. 11.
    Demirsoy, AC (1999). The MOS SF-36 health survey: a validation study with a Turkish sample. Thesis, Bogazici University, İstanbulGoogle Scholar
  12. 12.
    Jenkinson TR, Mallorie PA, Whitelock HC (1994) Defining spinal mobility in ankylosing spondylitis (AS): the Bath AS Metrology Index. J Rheumatol 21:1694–1698PubMedGoogle Scholar
  13. 13.
    Bodur H, Ataman S, Rezvani A et al (2011) Quality of life and related variables in patients with ankylosing spondylitis. Qual Life Res 20:543–549PubMedCrossRefGoogle Scholar
  14. 14.
    Salaffi F, Carotti M, Gasparini S, Intorcia M, Grassi W (2009) The health-related quality of life in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis: a comparison with a selected sample of healthy people. Health Qual Life Outcomes 7:25PubMedCrossRefGoogle Scholar
  15. 15.
    Ozgül A, Peker F, Taskaynatan MA, Tan AK, Dinçer K, Kalyon TA (2006) Effect of ankylosing spondylitis on health-related quality of life and different aspects of social life in young patients. Clin Rheumatol 25:168–174PubMedCrossRefGoogle Scholar
  16. 16.
    Turan Y, Duruöz MT, Cerrahoglu L (2007) Quality of life in patients with ankylosing spondylitis: a pilot study. Rheumatol Int 27:895–899PubMedCrossRefGoogle Scholar
  17. 17.
    Ariza–Ariza R, Hernández-Cruz B, Navarro-Sarabia F (2003) Physical function and health-related quality of life of Spanish patients with ankylosing spondylitis. Arthritis Rheum 49:483–487PubMedCrossRefGoogle Scholar
  18. 18.
    Rugiene R, Kirdaite G, Gražuleviciute E, Dadoniene J, Venalis V (2008) The quality of life and functional ability in patients with ankylosing spondylitis. Acta Med Lituanica 15:99–103Google Scholar
  19. 19.
    Zhao LK, Liao ZT, Li CH, Li TW, Wu J, Lin Q, Huang F, Yu DT, Gu JR (2007) Evaluation of quality of life using ASQoL questionnaire in patients with ankylosing spondylitis in a Chinese population. Rheumatol Int 27:605–611PubMedCrossRefGoogle Scholar
  20. 20.
    Tayel MY, Soliman E, El Baz WF, El Labaan A, Hamaad Y, Ahmed MH (2011) Registry of the clinical characteristics of spondyloarthritis in a cohort of Egyptian population. Rheumatol Int. 31 Aug 2011 [Epub ahead of print]Google Scholar
  21. 21.
    Brunner R, Kissling RO, Auckenthaler C, Fortin J (2002) Clinical evaluation of ankylosing spondylitis in Switzerland. Pain Physician 5:49–56PubMedGoogle Scholar
  22. 22.
    Dalyan M, Güner A, Tuncer S, Bilgiç A, Arasil T (1999) Disability in ankylosing spondylitis. Disabil Rehabil 21:74–79PubMedCrossRefGoogle Scholar
  23. 23.
    Aggarwal R, Malaviya AN (2009) Clinical characteristics of patients with ankylosing spondylitis in India. Clin Rheumatol 28:1199–1205PubMedCrossRefGoogle Scholar
  24. 24.
    Nazarinia MA, Ghaffarpasand F, Heiran HR, Habibagahi Z (2009) Pattern of ankylosing spondylitis in an Iranian population of 98 patients. Mod Rheumatol 19:309–315PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Özlem Yılmaz
    • 1
  • Ahmet Tutoğlu
    • 1
  • Yeşim Garip
    • 1
    • 2
  • Esra Özcan
    • 1
  • Hatice Bodur
    • 1
  1. 1.Department of Physical Medicine and RehabilitationNumune Training and Research HospitalSamanpazariTurkey
  2. 2.CankayaTurkey

Personalised recommendations