Rheumatology International

, Volume 33, Issue 2, pp 273–276 | Cite as

Leflunomide: friend or foe for systemic lupus erythematosus?

  • Guo-Cui Wu
  • Xiao-Di Xu
  • Qiong Huang
  • Hua WuEmail author
Review Article


Leflunomide is a new immunosuppressive medicine that has been effectively used in the therapy of rheumatoid arthritis and subsequently used with success in animal models and patients with systemic lupus erythematosus (SLE). However, its use has also been associated with significant and serious adverse reactions involving hematological, hepatic, immune, dermatological and respiratory systems. In the current review, we attempt to describe the two sides of this drug in the treatment of SLE.


Leflunomide Systemic lupus erythematosus Therapy 



This work is supported by the Scientific Research Funds of Anhui Medical University (2011xkj088) and the National Natural Science Foundation of China (81002192).

Conflict of interest

No competing financial interests exist.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of PharmacyBinhu Hospital, The First People’s Hospital of Hefei CityHefeiChina

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