Rheumatology International

, Volume 33, Issue 3, pp 681–688 | Cite as

Excess weight and associated risk factors in patients with systemic lupus erythematosus

  • Fabiana de Miranda Moura dos Santos
  • Mariane Curado BorgesEmail author
  • Rosa Weiss Telles
  • Maria Isabel T. D. Correia
  • Cristina Costa Duarte Lanna
Original Article


The objective of this study is to determine the socio-demographic, clinical and laboratory characteristics of outpatients with SLE who present with excess weight as well as to assess the immunosuppressive therapy used. One hundred and seventy women with SLE were evaluated consecutively in a transversal study. The relationship between excess weight and the patients’ characteristics was evaluated using univariate and multivariate Poisson regression analysis. Of the 170 patients evaluated, 109 presented with excess weight, two were malnourished and 59 were classified as eutrophic. Age and disease duration of those with excess weight were 42.4 ± 8.7 and 10.4 ± 6.2 years, respectively. Risk factors associated with excess weight were the following: age ≥40 years, <8 years of education, lack of occupation, damage index ≥1, systemic high blood pressure, diabetes mellitus and triglycerides ≥150 mg/dL levels. The use of antimalarial therapy and steroids was associated with a lower frequency of excess weight. Age ≥40 years and the non-usage of methotrexate were the variables independently associated with excess weight in the multivariate analysis. Patients with SLE who have excess weight present distinct clinical-laboratory findings, socio-demographic characteristics and treatment options when compared to normal weight patients. Prospective studies should assess whether these characteristics will interfere with the outcome or prognosis of lupus.


Systemic lupus erythematosus Excess weight Nutritional status 



We acknowledge the FAPEMIG (The State of Minas Gerais Research Foundation) for financial support and the CNPQ (Conselho Nacional de Desenvolvimento Científico e Tecnológico) for the research grant to Correia, MITD.

Conflict of interest

None of the authors has declared a conflict of interest.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Fabiana de Miranda Moura dos Santos
    • 1
  • Mariane Curado Borges
    • 2
    Email author
  • Rosa Weiss Telles
    • 1
  • Maria Isabel T. D. Correia
    • 3
  • Cristina Costa Duarte Lanna
    • 1
    • 4
  1. 1.Rheumatology Service, Hospital das Clínicas, Department of Locomotor System, School of MedicineUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.School of MedicineUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  3. 3.Department of Surgery, School of MedicineUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  4. 4.Department of Locomotor System, School of MedicineUniversidade Federal de Minas GeraisBelo HorizonteBrazil

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