Excess weight and associated risk factors in patients with systemic lupus erythematosus
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The objective of this study is to determine the socio-demographic, clinical and laboratory characteristics of outpatients with SLE who present with excess weight as well as to assess the immunosuppressive therapy used. One hundred and seventy women with SLE were evaluated consecutively in a transversal study. The relationship between excess weight and the patients’ characteristics was evaluated using univariate and multivariate Poisson regression analysis. Of the 170 patients evaluated, 109 presented with excess weight, two were malnourished and 59 were classified as eutrophic. Age and disease duration of those with excess weight were 42.4 ± 8.7 and 10.4 ± 6.2 years, respectively. Risk factors associated with excess weight were the following: age ≥40 years, <8 years of education, lack of occupation, damage index ≥1, systemic high blood pressure, diabetes mellitus and triglycerides ≥150 mg/dL levels. The use of antimalarial therapy and steroids was associated with a lower frequency of excess weight. Age ≥40 years and the non-usage of methotrexate were the variables independently associated with excess weight in the multivariate analysis. Patients with SLE who have excess weight present distinct clinical-laboratory findings, socio-demographic characteristics and treatment options when compared to normal weight patients. Prospective studies should assess whether these characteristics will interfere with the outcome or prognosis of lupus.
KeywordsSystemic lupus erythematosus Excess weight Nutritional status
We acknowledge the FAPEMIG (The State of Minas Gerais Research Foundation) for financial support and the CNPQ (Conselho Nacional de Desenvolvimento Científico e Tecnológico) for the research grant to Correia, MITD.
Conflict of interest
None of the authors has declared a conflict of interest.
- 1.World Health Organization. Fact sheet: obesity and overweight. Available at http://www.who.int/mediacentre. Accessed on: 11 Jun. 2008
- 10.Luiz RA, Magnanimi MMF (2004) Size of samples in epidemiological investigations In: Medronho R. Epidemiologia. 2a ed. São Paulo: Atheneu. Cap.10, p 415–427Google Scholar
- 11.V Brazilian Guidelines on Hypertension. Arq Bras Cardiol 2007;89(3):e24–e79Google Scholar
- 15.Gladman DD, Ginzler EM, Goldsmith C, Fortin P, Liang M, Urowitz M et al (1996) The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum 39:363–369PubMedCrossRefGoogle Scholar
- 17.Matsudo SM, Araújo T, Matsudo VR, Andrade D, Andrade E, Oliveira LC et al (2001) International physical activity questionnaire (IPAQ): reproducibility and validity study in Brazil. Rev Bras Física Saúde 6:5–18Google Scholar
- 18.Celafisc (2007) Physical activity classification—IPAQ. Brazil. Available at: http://www.celafisc.institucional.ws/65/questionarios.html. Accessed on 9 Sep. 2009
- 20.Ministry of Health. Surveillance and risk factors for chronic disease through telephone interviews. Brazil; 2008. Available at: http://www.saude.gov.br. Accessed on 2 Nov. 2009
- 25.Alarcón GS, McGwin GJr, Bastian HM, Roseman J, Lisse J, Fessler BJ et al (2001) for the Lumina study group Systemic Lupus Erythematosus in Three Ethnic Groups. VIII. Predictors of Early Mortality in the LUMINA Cohort. Arthritis Rheum 45(2):191–202Google Scholar
- 32.Fessler BJ, Alarcón G, McGwin Jr G, LUMINA Study Group et al (2005) Systemic lupus erythematosus in three ethnic groups: XVI. Association of hydroxychloroquine use with reduced risk of damage accrual. Arthritis Rheum 52:1473–1480Google Scholar